Thaum qhov kub thiab txias, cov roj cholesterol ua rau cov kua dej ua kom cov kua dej ntau dualos ntawm kev tiv thaiv cov lipids los ntawm kev ntim khoom sib ze. Thaum qhov kub thiab txias, cov roj (cholesterol) yuav txo qis hauv daim nyias nyias.
Puas cov roj (cholesterol) ua kom cov kua dej ntau dua lossis tsawg dua?
Nyob ntawm qhov kub thiab txias, cov roj (cholesterol) muaj qhov cuam tshuam sib txawv ntawm daim nyias nyias. Thaum qhov kub thiab txias, cov roj (cholesterol) cuam tshuam nrog kev txav ntawm cov phospholipid fatty acid chains, ua rau sab nrauv ntawm cov kua dej tsawg thiab txo nws cov permeability rau me me molecules.
YPuas cov roj (cholesterol) nce cov membrane permeability?
Lub luag haujlwm ntawm cov roj (cholesterol) hauv bilayer thiab monolayer lipid daim nyias nyias tau muaj txiaj ntsig zoo. Nyob rau hauv lub biophysical pem hauv ntej, cov roj cholesterol tau nce qhov kev txiav txim ntawm cov lipid packing, lowers cov membrane permeability, thiab tswj cov kua dej los ntawm kev tsim cov kua-qib-theem lipid rafts.
Vim li cas cov roj (cholesterol) qis dua membrane permeability?
Cov roj (cholesterol) cuam tshuam nrog cov fatty acid tails ntawm phospholipids kom nruab nrab cov khoom ntawm daim nyias nyias: Cov roj (cholesterol) ua haujlwm rau immobilize sab nrauv ntawm daim nyias nyias, txo cov fluidity. Nws ua rau cov membrane tsawg permeable rau me me dej-soluble molecules uas yuav txwv tsis pub hla.
Kev sib raug zoo ntawm cov roj (cholesterol) thiab daim nyias nyias yog dab tsi?
Cov roj (cholesterol) uaRaws li ib tug bidirectional regulator ntawm membrane fluidity vim hais tias ntawm qhov kub thiab txias,nws stabilizes daim nyias nyias thiab tsa nws melting point, whereas nyob rau hauv qis kub nws intercalates ntawm phospholipids thiab tiv thaiv lawv los ntawm clustering ua ke thiab stiffening.
