Ribonucleotide excision kho (RER) yog pib los ntawm RNase H2 thiab ua rau muaj kev tsis raug tshem tawm ntawm xws li mis-incorporated ribonucleotides. Yog tias tsis kho, DNA-embedded ribonucleotides ua rau muaj ntau yam kev hloov pauv hauv chromosomal DNA, uas thaum kawg ua rau genome instability.
Nucleotide excision kho yog dab tsi thiab nws siv rau dab tsi?
Nucleotide excision kho (NER) yog txoj hauv kev tseem ceeb siv los ntawm cov tsiaj nyeg kom tshem tawm cov kab mob DNA loj xws li cov tsim los ntawm UV teeb, ib puag ncig mutagens, thiab qee cov kab mob qog noj ntshav los ntawm DNA. Qhov tsis zoo hauv NER yog cuam tshuam nrog kev mob qog noj ntshav ntawm daim tawv nqaij uas muaj feem cuam tshuam los ntawm xeroderma pigmentosum.
txhais li cas los ntawm kev kho nucleotide?
Definition. Nucleotide excision kho yog txheej txheem uas kho kev puas tsuaj rau ib txoj hlua DNA, tshwj xeeb yog los ntawm UV irradiation, uas cuam tshuam cov DNA helix. Lub DNA flanking qhov chaw puas tsuaj yog cleaved los tsim ib tug ib leeg-stranded sib txawv uas yog kho los ntawm luam the undamaged strand los restore ib tug helix.
Yuav ua li cas nrog kev kho nucleotide?
Nyob rau hauv nucleotide excision kho (NER), puas hauv paus raug txiav tawm hauv ib txoj hlua ntawm nucleotides, thiab hloov nrog DNA raws li qhia los ntawm cov qauv tsis raug puas. Qhov kev kho no yog siv los tshem tawm pyrimidine dimers tsim los ntawm UV hluav taws xob nrog rau nucleotides hloov kho los ntawm cov tshuaj loj heev.adducts.
Yuav ua li cas kho qhov kev txiav txim?
Kev kho qhov txiav yuav muaj tshem tawm ntawm cov nucleotide puas los ntawm ob qhov kev phais bracketing qhov txhab; Qhov no yog ua tiav los ntawm multisubunit enzyme hu ua excision nuclease lossis excinuclease.
