Ntau qhov kev tshawb fawb tsis ntev los no tau qhia tias antiangiogenic tyrosine kinase inhibitors (TKIs) tsom ntau yam ntawm cov qog microenvironment thiab yog cov chav kawm zoo tshaj plaws ntawm cov neeg ua haujlwm rau kev sib koom ua ke nrog kev kho mob qog noj ntshav.
Puas yog tyrosine kinase inhibitors immunosuppressive?
Ua ke, muaj pov thawj ntawm muaj peev xwm tiv thaiv kab mob ntawm TKIs cuam tshuam rau BCR-ABL, feem ntau yuav yog vim lawv qhov kev ua tsis tau raws li lub hom phiaj.
Puas kinase inhibitors ua rau kev tiv thaiv kab mob?
Cov teebmeem ntawm tyrosine kinase inhibitors ntawm lub cev tiv thaiv kab mob.
Txawm li cas los xij, macrophages, suav nrog M1 thiab M2 hlwb, tuaj yeem koom nrog immunosuppressive xeev hauv cov qog- bearing host. Feem ntau, M2 macrophages paub tias yog kev tiv thaiv kab mob los ntawm kev tsim IL-10 thiab arginase.
Puas yog tyrosine kinase inhibitors chemotherapy?
Txhua yam tshuaj siv los kho mob qog noj ntshav (xws li tyrosine kinase inhibitors lossis TKIs) tuaj yeem suav hais tias yog chemo, tab sis ntawm no chemo yog siv los txhais tau tias kev kho mob nrog cov pa cytotoxic (cell-tua) cov tshuaj uas feem ntau tua cov hlwb uas loj hlob thiab faib sai. Chemo yog ib qho kev kho mob tseem ceeb rau CML.
Kev kho kinase inhibitor yog dab tsi?
Tyrosine kinase inhibitors (TKIs) yog hom kev kho mob. TKIs tuaj ua tshuaj, noj qhov ncauj. Txoj kev kho lub hom phiaj txheeb xyuas thiab tawm tsam qee hom mob qog noj ntshav thaum ua rau muaj kev puas tsuaj tsawg rau cov hlwb ib txwm.
