Gramicidin A (1, Fig. 1a), nrhiav pom hauv 1939 los ntawm cov kab mob hauv av Bacillus brevis 11 , 12, yog thawj cov tshuaj tua kab mob tsim tawm lag luam13, 14. Cov khoom lag luam peptidic no qhia txog cov tshuaj tua kab mob dav dav uas muaj zog tiv thaiv kab mob Gram-zoo, txawm tias muaj ntau hom tshuaj tiv thaiv kab mob 15.
Leej twg nrhiav tau gramicidin?
Nyob rau xyoo 1939, René Dubos nrhiav pom gramicidin-tus thawj kws tshuaj ntsuam xyuas tshuaj tua kab mob.
Thaum twg amoxicillin pom thawj zaug?
Amoxicillin tau tshawb pom los ntawm cov kws tshawb fawb ntawm Beecham Research Laboratories hauv 1972. Qhov nqaim ntawm cov tshuaj tua kab mob ntawm cov tshuaj tua kab mob ntawm penicillins, coj mus rau kev tshawb nrhiav cov derivatives ntawm penicillin uas tuaj yeem kho ntau yam kab mob. Thawj kauj ruam tseem ceeb rau pem hauv ntej yog kev txhim kho ampicillin.
pom gramicidin nyob qhov twg?
Gramicidin S yog ib qho piv txwv ntawm CPs tau los ntawm cov kab mob (Fig. 4.1). Nws yog ib tug cyclic decapeptide, muab rho tawm nonribosomally los ntawm cov av kab mob Aneurinibacillus, nrog ib tug antiparallel β-daim ntawv tsim los ntawm ob zoo tib yam pentapeptides koom lub taub hau rau tus Tsov tus tw, officially sau raws li cyclo(-Val-Orn-Leu-d-Phe-Pro-)2 [47, 48].
Yuav ua li cas hom tshuaj tua kab mob yog gramicidin?
Gramicidin D yog tshuaj tua kab mob bactericidal siv los kho cov kab mob dermatological thiab ophthalmic.
