Nicotinic receptors muaj nyob rau hauv: Lub somatic paj hlwb(neuromuscular junctions hauv cov leeg pob txha). Lub sympathetic thiab parasympathetic paj hlwb (autonomic ganglia). Lub hauv paus paj hlwb (Sib tham tom qab).
Nco nicotine receptors nyob rau hauv lub hlwb nyob qhov twg?
Nicotine receptors nyob thoob plaws hauv lub hlwb suav nrog lub cortex, hippocampus, basal ganglia, thalamus, cerebellum, basal forebrain, thiab brainstem, nrog rau cov retina thiab cochlea. Lawv tsis zoo ib yam li muscarinic receptors nyob rau hauv lub hauv paus paj hlwb.
Puas muaj nicotinic receptors?
Cov nicotinic acetylcholine receptors (nAChRs) yog cov nkag siab zoo tshaj plaws ntawm cov membrane receptors rau neurotransmitters ntawm cov qauv thiab kev ua haujlwm. Lawv yog ib qho tseem ceeb allosteric membrane proteins uas muaj tsib zoo tib yam los yog homologous subunits symmetrically teem ib ncig ntawm ib tug central ionic channel.
Dab tsi receptors tau qhib los ntawm nicotine?
Main. Cov teebmeem physiological ntawm nicotine yog kho los ntawm kev khi rau, thiab ua kom, nicotinic acetylcholine receptors (nAChRs). Cov nAChRs no yog pentamers ua los ntawm cov subunits uas muaj qhov sib txawv, tab sis sib tshooj qhia cov qauv hauv subsets ntawm neurons.
Puas yog nicotine ua kom muaj zog?
Cov pov thawj tseem ceeb qhia tau tias nicotine, zoo li lwm yam tshuaj ntawm kev tsim txom, ua rau nws cuam tshuam rau tus cwj pwm los ntawm ua kom lub mesocorticolimbic dopamine (DA) system, ib txoj hauv kev los ntawm thaj chaw ventral tegmental (VTA) thiab projecting mus rau lub nucleus accumbens (NAcc) thiab lwm qhov chaw forebrain.
