Dopamine receptors tau qhia nyob rau hauv lub hauv paus paj hlwb, tshwj xeeb hauv hippocampal dentate gyrus thiab subventricular zone. Dopamine receptors kuj qhia nyob rau hauv lub periphery, prominently nyob rau hauv lub raum thiab vasculature, Muaj tsib hom dopamine receptors, uas muaj xws li D1, D2, D3, D4, thiab D5.
Dopamine receptors hauv lub hlwb yog dab tsi?
Dopamine receptors yog G protein-coupled receptors koom nrog hauv kev tswj hwm ntawm lub cev muaj zog thiab ntau yam kev puas hlwb xws li schizophrenia, kev puas siab puas ntsws bipolar, Parkinson's disease (PD), Alzheimer's disease, thiab mloog-deficit/hyperactivity disorder.
dopamine 2 receptor nyob qhov twg?
Lub D5 receptor tau raug anatomically localized rau lub cortex, hippocampus thiab limbic system. D2. Cov dopamine D2 receptors txuas nrog inhibitory G-proteins thiab pib ua haujlwm los ntawm inhibiting enzyme adenylate cyclase. Lub D2 receptors tau nyob hauv ob qho tib si presynaptically thiab postsynaptically.
Puas muaj dopamine receptors hauv lub siab?
Dopamine receptors yog faib rau hauv phab ntsa ntawm ob qho tib si atria thiab ventricles, thiab nws cov kev hloov pauv hloov pauv tuaj yeem piav qhia hauv phab ntsa ntawm tib neeg lub siab. Cov ntu ntawm atria thiab ventricles raug rau cov tshuaj tiv thaiv antidopamine receptor antibodies pom cov tshuaj tiv thaiv fluorescent-zoo nyob rau hauv epicardium, myocardium thiab endocardium.
Lub luag haujlwm yog dab tsintawm dopamine D2 receptors?
Dopamine D2 receptor activation induces pathways koom tes hauv kev sib txawv ntawm tes, kev loj hlob, metabolism, thiab apoptosis, tshwj xeeb tshaj yog ERK thiab / lossis MAPK txoj hauv kev. Interestingly, antiproliferative teebmeem tau txuam nrog qhov ua kom no.
