Kev hloov pauv cov roj cholesterol mus rau pregnenolone yog ua tiav los ntawm kev sib cais ntawm cov roj cholesterol sab saw, catalyzed los ntawm mitochondrial cytochrome P450 enzyme hu ua P450scc, qhov twg scc xaiv cov saw cleavage.
Qhov enzyme twg yog lub luag haujlwm rau kev hloov cov roj cholesterol mus rau progesterone?
Kev hloov pauv ntawm pregnenolone rau progesterone yog catalyzed los ntawm enzyme 3β-ol-dehydrogenase Δ 5 / Δ 4isomerase; Cov txheej txheem muaj dehydrogenation ntawm hydroxyl pawg C-3 ntawm pregnenolone, yielding ib pawg keto, nrog rau tom qab tsiv teb tsaws ntawm ob daim ntawv cog lus los ntawm C-5-C-6 mus rau C-4-C-5 (khoom, progesterone).
Cov roj cholesterol ua li cas thiaj ua tau pregnenolone?
Hauv mitochondria, cov roj cholesterol hloov mus rau pregnenolone los ntawm ib qho enzyme nyob rau hauv daim nyias nyias hu ua CYP11A1. Pregnenolone nws tus kheej tsis yog cov tshuaj hormones, tab sis yog qhov ua ntej tam sim rau kev sib txuas ntawm tag nrho cov tshuaj steroid.
Yuav ua li cas enzyme xav tau rau cov roj cholesterol hloov mus rau Pregenolone?
Side chain cleavage enzyme (tseem hu ua cholesterol desmolase) yog cytochrome P450 enzyme encoded los ntawm CYP11A1 noob nyob ntawm chromosome 15q23-q24. Qhov enzyme no hloov cov roj cholesterol mus rau pregnenolone, yog qhov tseem ceeb rau steroidogenesis, thiab ua lub luag haujlwm tseem ceeb hauv placental progesterone synthesis.
pregnenolone yog tsim los ntawm dab tsi?
Pregnenolone yog ib yam tshuaj hormones tsim nyob rau hauvlub cev los ntawm cov qog adrenal. Pregnenolone kuj yog tsim los ntawm cholesterol, thiab yog cov khoom pib hauv kev tsim cov testosterone, progesterone, cortisol, estrogen thiab lwm yam tshuaj hormones.
