Yog li, yog tias muaj kev hloov pauv, piv txwv li, kev ntxig lossis tshem tawm ntawm nucleotide, tshwm sim, qhov no tuaj yeem ua rau kev hloov pauv ntawm kev nyeem ntawv. Nws hloov tag nrho cov amino acid ib ntus. Cov kev hloov pauv no yog hu ua frameshift mutation (tseem hu ua kev nyeem ntawv hloov pauv, nyeem ntawv hloov pauv, lossis framing yuam kev).
Puas ntxig ua rau kev hloov pauv hloov pauv?
A frameshift mutation is a genetic mutation ua los ntawm kev rho tawm lossis tso rau hauv DNA ib ntus uas hloov txoj kev nyeem ib ntus. DNA sib lawv liag yog ib tug saw ntawm ntau me me molecules hu ua nucleotides.
Puas yog qhov taw qhia lossis qhov hloov pauv hloov pauv?
Kev hloov pauv hloov pauv yog tsim los ntawm kev ntxig lossis tshem tawm ntawm ib lossis ntau lub hauv paus tshiab. Vim tias qhov kev nyeem ntawv pib ntawm qhov chaw pib, txhua mRNA uas tsim los ntawm cov DNA hloov pauv yuav raug nyeem tawm ntawm tus ncej tom qab lub ntsiab lus ntawm qhov ntxig lossis tshem tawm, ua rau cov protein tsis muaj txiaj ntsig.
Dab tsi ua rau kev hloov pauv hloov pauv?
Frameshift mutation yog tshwm sim los ntawm qhov sib ntxiv lossis rho tawm ntawm nucleotides los ntawm DNA ntu. Vim hais tias cov noob caj noob ces yog nyeem nyob rau hauv triplets, ntxiv los yog rho tawm ntawm 1 los yog 2 nucleotides ua rau ib tug hloov nyob rau hauv tus nyeem ntawv ncej.
Kev hloov pauv dab tsi tshwm sim los ntawm kev ntxig?
Ib qho kev hloov pauv tshwm sim thaum ib qho ntxiv nucleotide ntxiv rau DNAstrand thaum replication. Qhov no tuaj yeem tshwm sim thaum cov kab rov ua dua "slip," lossis wrinkles, uas tso cai rau cov nucleotide ntxiv rau kev koom ua ke (Daim duab 2). Strand slippage kuj tuaj yeem ua rau tshem tawm kev hloov pauv.
