Acetylide (alkynide) anions yog muaj zog hauv paus thiab muaj zog nucleophiles. Yog li ntawd, lawv muaj peev xwm tshem tawm halides thiab lwm pab pawg tawm hauv kev hloov pauv.
Acetylide anion yog dab tsi?
Ib acetylide anion yog anion tsim los ntawm kev tshem tawm cov proton los ntawm qhov kawg carbon ntawm lub davhlau ya nyob twg alkyne: Cov kua qaub yog cov npe ntawm cov khoom sib xyaw ua ke kom nce lossis txo cov kua qaub..
NaNH2 puas yog cov kua qaub lossis lub hauv paus?
NaNH2 yog a muaj zog hauv paus, npaj kom muaj zog txaus kom deprotonate cov alkyne (pKa ≈ 25).
Puas alkyne muaj zog Nucleophile?
Terminal Alkynes - Cov tshuaj tiv thaiv raws li Acid
Terminal alkynes tau nkag mus rau alkynide (acetylide) ions nrog cov hauv paus muaj zog xws li NaNH2 thiab NaH. Cov alkynide ions yog muaj zog nucleophiles, muaj peev xwm ua haujlwm nrog electrophiles xws li alkyl halides thiab epoxides.
NaNH2 puas yog lub hauv paus muaj zog lossis nucleophile?
Yuav siv li cas rau: NaNH2 yog a muaj zog. Hauv qhov tsis tshua muaj tshwm sim thaum nws qhov muaj zog hauv paus tsis ua rau muaj kev cuam tshuam sab nraud, nws tuaj yeem ua ib qho zoo heev nucleophile Nws yog siv rau deprotonation ntawm cov acids tsis muaj zog thiab kuj rau kev tshem tawm cov tshuaj tiv thaiv. Zoo ib yam li: LDA (lithium diisopropylamide).
