Unconjugated bilirubin yog cov khoom pov tseg ntawm hemoglobin tawg uas tau coj los ntawm lub siab, qhov twg nws hloov pauv los ntawm enzyme uridine diphosphoglucuronate glucuronosyltransferase (UGT) rau hauv conjugated bilirubin. Conjugated bilirubin yog dej-soluble thiab tawm mus rau hauv cov kua tsib kom tshem tawm ntawm lub cev.
Qhov twg yog qhov ntau tshaj unconjugated bilirubin?
Vim tias tsis muaj teeb meem nrog lub siab lossis cov kab mob hauv lub cev, qhov ntau dhau ntawm bilirubin yuav dhau mus tag nrho cov txheej txheem ua haujlwm ib txwmuas tshwm sim (piv txwv li, conjugation, excretion hauv cov kua tsib., metabolism hauv urobilinogen, reabsorption) thiab yuav tshwm sim raws li qhov nce ntawm urobilinogen hauv cov zis.
Puas yog unconjugated bilirubin pom hauv cov kua tsib?
Bilirubin yog xim daj daj muaj nyob hauv bile. Nws yog tsim thaum lub siab tawg cov qe ntshav liab qub. Bilirubin raug tshem tawm ntawm lub cev los ntawm cov quav (quav) thiab muab cov quav tso rau nws cov xim ib txwm muaj.
Puas tsis muaj bilirubin pom hauv cov zis?
Unconjugated: Albumin-bound hauv cov ntshav. Ntsuas raws li indirect-reacting bilirubin. Tsis muaj zis hauv zis.
qhov sib txuas ntawm bilirubin nyob qhov twg?
Bilirubin yog conjugated hauv lub hepatocyterau glucuronic acid los ntawm tsev neeg ntawm enzymes, hu ua uridine-diphosphoglucuronic glucuronosyltransferase (UDPGT). Cov txheej txheem ntawm glucuronidation yog ib qho ntawm ntau qhov tseem ceeb detoxification mechanisms ntawmtib neeg lub cev.
