2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Kev hloov pauv ntawm epithelial-to-mesenchymal (EMT) tshwm sim thaum lub sijhawm kev loj hlob ntawm embryonic, kev tsim cov ntaub so ntswg, kab mob hauv lub cev, thiab kho qhov txhab. Nws yog cov txheej txheem muaj zog heev, uas cov hlwb epithelial tuaj yeem hloov mus rau hauv mesenchymal phenotype.
txhais li cas los ntawm kev hloov pauv ntawm epithelial-rau-mesenchymal?
Kev hloov pauv ntawm epithelial-mesenchymal (EMT) yog cov txheej txheem biologic uas tso cai rau lub cell polarized epithelial, uas feem ntau cuam tshuam nrog hauv qab daus daim nyias nyias ntawm nws qhov chaw basal, kom tau txais ntau yam kev hloov pauv biochemical uas ua rau nws xav tau. mesenchymal cell phenotype, uas suav nrog kev txhim kho kev tsiv teb tsaws chaw, …
Lub hom phiaj ntawm kev hloov pauv epithelial-mesenchymal yog dab tsi?
Kev hloov pauv ntawm epithelial–mesenchymal (EMT) yog tseem ceeb rau kev loj hlob ntawm embryonic thiab tsim ntawm ntau cov ntaub so ntswg lossis kabmob. Txawm li cas los xij, EMT tsis ua haujlwm hauv cov hlwb ib txwm ua rau cov kab mob, xws li mob qog noj ntshav lossis fibrosis. Thaum lub sij hawm EMT, cov hlwb epithelial tau hloov mus rau hauv ntau invasive thiab nquag mesenchymal hlwb.
Dab tsi ua rau kev hloov pauv ntawm epithelial-mesenchymal?
Metastasis ntawm cov qog hlwb yog txuam nrog kev hloov pauv ntawm epithelial-to-mesenchymal (EMT), uas yog cov txheej txheem uas cov hlwb epithelial poob lawv cov polarity thiab tau txais cov yam ntxwv tshiab ntawm mesenchyme. EMT tau raug tshaj tawm tias yuav raug ntxias los ntawm hloov pauv kev loj hlob-β1 (TGF-β1), tab sis nws cov txheej txheem tseem tsis tau paub.
Thaum twg EMTtshwm sim?
Ib qho piv txwv ntawm thawj EMT tshwm sim thaum lub plab zom mov, qhov chaw embryonic epithelium dhau EMT los ua mesoderm. Hauv vertebrates, gastrulation yog ntxias los ntawm cov proteins los ntawm kev hloov pauv kev loj hlob β (TGFβ) superfamily, tshwj xeeb tshaj yog Nodal thiab Vg1 [5][6].
Pom zoo:
Dab tsi yog qhov hloov pauv thiab hloov pauv hloov pauv?
Point mutations hloov ib leeg nucleotide. Frameshift kev hloov pauv yog ntxiv lossis tshem tawm ntawm nucleotides uas ua rau muaj kev hloov pauv hauv kev nyeem ntawv. frameshift thiab point mutation yog dab tsi? Ib qho kev hloov pauv cuam tshuam rau ib khub hauv paus.
Puas yog jurassic ntiaj teb hloov pauv hloov pauv hloov pauv?
Qee zaum, paub meej, koj yuav tau rov qab mus rau lub sijhawm dhau los - txuag manually, thiab feem ntau, raws li game's autosave yog… tsis zam txim - tab sis feem ntau ntawm cov lub sijhawm koj tuaj yeem khaws cov khoom thiab khaws cia nrog.
Qhov twg yog qhov kev hloov pauv hloov pauv hloov pauv?
Semiconservative replication piav qhia txog cov txheej txheem ntawm DNA replication nyob rau hauv tag nrho cov paub hlwb. DNA replication tshwm sim ntawm ntau lub hauv paus pib ntawm kev rov ua dua raws DNA qauv strand. Raws li DNA ob chav helix yog unwound by helicase, replication tshwm sim nyias ntawm txhua tus qauv strand nyob rau hauv antiparallel cov lus qhia.
Qhov kev hloov pauv twg yog xav tias yuav cuam tshuam los ntawm kev hloov pauv hloov pauv?
Dependent Variable Qhov sib txawv uas nyob ntawm lwm yam uas ntsuas. Cov kev hloov pauv no yuav tsum tau hloov pauv raws li qhov kev sim ua haujlwm ntawm tus kheej hloov pauv lossis hloov pauv. Nws yog cov nyhuv presumed. Qhov kev tshawb fawb hloov pauv twg yog qhov tshwm sim?
Los ntawm kev hloov pauv hloov pauv hloov pauv?
Kev hloov pauv hloov pauv hloov pauv (TMA) yog qhov isothermal (tsis hloov pauv nucleic acid kub), ib leeg-tube nucleic acid amplification system siv ob lub enzymes, RNA polymerase thiab thim rov qab kev sau ntawv. … Cov txheej txheem no tuaj yeem siv los tsom rau RNA thiab DNA.
