Kev hloov pauv ntawm epithelial-to-mesenchymal (EMT) tshwm sim thaum lub sijhawm kev loj hlob ntawm embryonic, kev tsim cov ntaub so ntswg, kab mob hauv lub cev, thiab kho qhov txhab. Nws yog cov txheej txheem muaj zog heev, uas cov hlwb epithelial tuaj yeem hloov mus rau hauv mesenchymal phenotype.
txhais li cas los ntawm kev hloov pauv ntawm epithelial-rau-mesenchymal?
Kev hloov pauv ntawm epithelial-mesenchymal (EMT) yog cov txheej txheem biologic uas tso cai rau lub cell polarized epithelial, uas feem ntau cuam tshuam nrog hauv qab daus daim nyias nyias ntawm nws qhov chaw basal, kom tau txais ntau yam kev hloov pauv biochemical uas ua rau nws xav tau. mesenchymal cell phenotype, uas suav nrog kev txhim kho kev tsiv teb tsaws chaw, …
Lub hom phiaj ntawm kev hloov pauv epithelial-mesenchymal yog dab tsi?
Kev hloov pauv ntawm epithelial–mesenchymal (EMT) yog tseem ceeb rau kev loj hlob ntawm embryonic thiab tsim ntawm ntau cov ntaub so ntswg lossis kabmob. Txawm li cas los xij, EMT tsis ua haujlwm hauv cov hlwb ib txwm ua rau cov kab mob, xws li mob qog noj ntshav lossis fibrosis. Thaum lub sij hawm EMT, cov hlwb epithelial tau hloov mus rau hauv ntau invasive thiab nquag mesenchymal hlwb.
Dab tsi ua rau kev hloov pauv ntawm epithelial-mesenchymal?
Metastasis ntawm cov qog hlwb yog txuam nrog kev hloov pauv ntawm epithelial-to-mesenchymal (EMT), uas yog cov txheej txheem uas cov hlwb epithelial poob lawv cov polarity thiab tau txais cov yam ntxwv tshiab ntawm mesenchyme. EMT tau raug tshaj tawm tias yuav raug ntxias los ntawm hloov pauv kev loj hlob-β1 (TGF-β1), tab sis nws cov txheej txheem tseem tsis tau paub.
Thaum twg EMTtshwm sim?
Ib qho piv txwv ntawm thawj EMT tshwm sim thaum lub plab zom mov, qhov chaw embryonic epithelium dhau EMT los ua mesoderm. Hauv vertebrates, gastrulation yog ntxias los ntawm cov proteins los ntawm kev hloov pauv kev loj hlob β (TGFβ) superfamily, tshwj xeeb tshaj yog Nodal thiab Vg1 [5][6].
