Ig isotype switching tshwm sim los ntawm qhov kev tshwm sim intrachromosomal deletional recombination tshwm sim, kos duab hauv daim duab 1 rau tus nas H saw locus. Tib neeg H saw locus zoo sib xws tab sis tsis zoo ib yam.
Thaum twg isotype hloov pauv tshwm sim?
CSR tshwm sim sai heev tom qab kis kab mob lossis txhaj tshuaj, ua ntej tsim cov chaw tua kab mob, uas feem ntau tsim 7-10 hnub tom qab kis rau cov tshuaj tiv thaiv.
Isotype hloov pauv tshwm sim nyob rau hauv lub cev qhov twg?
Cov chaw rov ua dua ntawm DNA lub npe hu ua 'hloov thaj chaw' tau pom nyob rau hauv cov dej ntws ntawm txhua tus isotype gene, uas yog siv los coj AID thiab lwm yam enzymes rau lub xaib.
Yuav ua li cas thaum hloov isotype?
Immunoglobulin chav hloov pauv (lossis isotype hloov pauv, lossis isotypic commutation, lossis chav hloov pauv hloov pauv (CSR)) yog cov txheej txheem lom neeg uas hloov B cell tsim cov tshuaj tiv thaiv los ntawm ib chav mus rau lwm qhov; Piv txwv li, los ntawm ib qho isotype hu ua IgM mus rau isotype hu ua IgG.
Dab tsi ua rau isotype hloov pauv?
Kev hloov chav kawm tshwm sim tom qab ua kom muaj cov kab mob B paub tab ntawm nws cov membrane-bound antibody molecule (los yog B cell receptor)los tsim cov chav sib txawv ntawm cov tshuaj tiv thaiv, tag nrho nrog tib yam. variable domains raws li tus thawj antibody generated nyob rau hauv lub immature B cell thaum lub sij hawm tus txheej txheem ntawm V(D)J recombination, tab sis muaj …
