2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Ig isotype switching tshwm sim los ntawm qhov kev tshwm sim intrachromosomal deletional recombination tshwm sim, kos duab hauv daim duab 1 rau tus nas H saw locus. Tib neeg H saw locus zoo sib xws tab sis tsis zoo ib yam.
Thaum twg isotype hloov pauv tshwm sim?
CSR tshwm sim sai heev tom qab kis kab mob lossis txhaj tshuaj, ua ntej tsim cov chaw tua kab mob, uas feem ntau tsim 7-10 hnub tom qab kis rau cov tshuaj tiv thaiv.
Isotype hloov pauv tshwm sim nyob rau hauv lub cev qhov twg?
Cov chaw rov ua dua ntawm DNA lub npe hu ua 'hloov thaj chaw' tau pom nyob rau hauv cov dej ntws ntawm txhua tus isotype gene, uas yog siv los coj AID thiab lwm yam enzymes rau lub xaib.
Yuav ua li cas thaum hloov isotype?
Immunoglobulin chav hloov pauv (lossis isotype hloov pauv, lossis isotypic commutation, lossis chav hloov pauv hloov pauv (CSR)) yog cov txheej txheem lom neeg uas hloov B cell tsim cov tshuaj tiv thaiv los ntawm ib chav mus rau lwm qhov; Piv txwv li, los ntawm ib qho isotype hu ua IgM mus rau isotype hu ua IgG.
Dab tsi ua rau isotype hloov pauv?
Kev hloov chav kawm tshwm sim tom qab ua kom muaj cov kab mob B paub tab ntawm nws cov membrane-bound antibody molecule (los yog B cell receptor)los tsim cov chav sib txawv ntawm cov tshuaj tiv thaiv, tag nrho nrog tib yam. variable domains raws li tus thawj antibody generated nyob rau hauv lub immature B cell thaum lub sij hawm tus txheej txheem ntawm V(D)J recombination, tab sis muaj …
Pom zoo:
Dab tsi yog qhov hloov pauv thiab hloov pauv hloov pauv?
Point mutations hloov ib leeg nucleotide. Frameshift kev hloov pauv yog ntxiv lossis tshem tawm ntawm nucleotides uas ua rau muaj kev hloov pauv hauv kev nyeem ntawv. frameshift thiab point mutation yog dab tsi? Ib qho kev hloov pauv cuam tshuam rau ib khub hauv paus.
Qhov kev hloov pauv no puas yuav ua rau muaj kev hloov pauv hloov pauv?
Yog li, yog tias muaj kev hloov pauv, piv txwv li, kev ntxig lossis tshem tawm ntawm nucleotide, tshwm sim, qhov no tuaj yeem ua rau kev hloov pauv ntawm kev nyeem ntawv. Nws hloov tag nrho cov amino acid ib ntus. Cov kev hloov pauv no yog hu ua frameshift mutation (tseem hu ua kev nyeem ntawv hloov pauv, nyeem ntawv hloov pauv, lossis framing yuam kev).
Puas yog jurassic ntiaj teb hloov pauv hloov pauv hloov pauv?
Qee zaum, paub meej, koj yuav tau rov qab mus rau lub sijhawm dhau los - txuag manually, thiab feem ntau, raws li game's autosave yog… tsis zam txim - tab sis feem ntau ntawm cov lub sijhawm koj tuaj yeem khaws cov khoom thiab khaws cia nrog.
Qhov twg yog qhov kev hloov pauv hloov pauv hloov pauv?
Semiconservative replication piav qhia txog cov txheej txheem ntawm DNA replication nyob rau hauv tag nrho cov paub hlwb. DNA replication tshwm sim ntawm ntau lub hauv paus pib ntawm kev rov ua dua raws DNA qauv strand. Raws li DNA ob chav helix yog unwound by helicase, replication tshwm sim nyias ntawm txhua tus qauv strand nyob rau hauv antiparallel cov lus qhia.
Qhov kev hloov pauv twg yog xav tias yuav cuam tshuam los ntawm kev hloov pauv hloov pauv?
Dependent Variable Qhov sib txawv uas nyob ntawm lwm yam uas ntsuas. Cov kev hloov pauv no yuav tsum tau hloov pauv raws li qhov kev sim ua haujlwm ntawm tus kheej hloov pauv lossis hloov pauv. Nws yog cov nyhuv presumed. Qhov kev tshawb fawb hloov pauv twg yog qhov tshwm sim?
