Lus xaus: Muaj pov thawj qhia tias edema yog ib chav kawm ntawm cov thiazolidinediones thiab yog ntau yam hauv keeb kwm. Thiazolidinedione-associated edema zoo li koob tshuaj cuam tshuam thiab tshwm sim feem ntau thaum thiazolidinediones siv ua ke nrog insulin.
Vim li cas thiazolidinediones ua rau edema?
Ntau cov ntaub ntawv pov thawj qhia tias PPARγ tswj ntau yam ntawm vascular muaj nuj nqi, suav nrog capillary permeability. Kev nce capillary permeability ua rau cov kua dej ntau ntxivthiab xav tias yuav pab txhawb rau cov neeg mob kho nrog TZDs.
Cov kev mob tshwm sim ntawm thiazolidinediones yog dab tsi?
Cov teebmeem ntawm glitazones tuaj yeem suav nrog:
- dej tuav.
- hnyav nce.
- teeb meem qhov muag.
- txo qis kev kov.
- mob plab thiab kab mob.
- ua xua daim tawv nqaij.
Leej twg yuav tsum tsis txhob noj thiazolidinediones?
[24] Kev pheej hmoo siab ntawm pob txha: Vim muaj kev pheej hmoo ntawm pob txha ntau ntxiv, cov neeg mob uas muaj kev pheej hmoo siab ntawm pob txha, xws li cov neeg muaj keeb kwm ntawm pob txha, cov poj niam postmenopausal, lossis cov neeg mob noj lwm cov tshuaj uas ua rau muaj kev pheej hmoo ntawm pob txha (xws li glucocorticoids thiab PPIs), yuav tsum tsis txhob pib ntawm TZD therapy.
Vim li cas thiazolidinediones contraindicated hauv plawv tsis ua hauj lwm?
Lub tshuab ntawm lub plawv tsis ua haujlwm vim yog thiazolidinedionesvia kua dej (Daim duab 1). Ob leeg cov neeg ua haujlwm no ua rau lub raum peroxisome proliferator-activated receptor gamma (PPAR gamma) thiab ua rau kom muaj sodium retention, kua dej, thiab ua rau lub plawv tsis ua hauj lwm ntawm cov neeg mob ntshav qab zib.
THIAZOLIDINEDIONES What You Need to Know
