2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
V(D)J recombination yuav nyiam tshwm sim hauv G1 theem ntawm lub voj voog ntawm tes. Cov kev sim tsis ntev los no nrog cov tshuaj tiv thaiv murine RAG2 qhia tias RAG2 protein ntau yog 20-fold ntau nyob rau hauv G1 cell voj voog theem dua li hauv S, G2, los yog M rau pre-B hlwb los yog thymocytes (Lin thiab Desiderio, 1994).
Vdj recombination tshwm sim theem twg?
V(D)J recombination yog lub tshuab ntawm somatic recombination uas tshwm sim tsuas yog hauv kev tsim cov lymphocytes thaum theem pib ntawm T thiab B cell maturation. Nws ua rau muaj ntau haiv neeg repertoire ntawm cov tshuaj tiv thaiv / immunoglobulins thiab T cell receptors (TCRs) pom nyob rau hauv B hlwb thiab T hlwb, feem.
Vdj recombination tshwm sim li cas?
VDJ recombination yog txheej txheem los ntawm uas T cells thiab B hlwb random sib sau ua ke cov noob sib txawv - paub tias sib txawv (V), ntau haiv neeg (D) thiab koom nrog (J) noob - txhawm rau tsim cov receptors tshwj xeeb (lub npe hu ua antigen receptors) uas tuaj yeem paub txog ntau hom molecule.
T cell somatic recombination tshwm sim nyob qhov twg?
Somatic recombination tshwm sim physiologically hauv sib dhos ntawm B cell receptor thiab T-cell receptor genes (V(D)J recombination), nrog rau hauv chav kawm hloov ntawm immunoglobulins. Somatic recombination kuj tseem ceeb hauv cov txheej txheem ntawm carcinogenesis.
Lub cev tiv thaiv kab mob dab tsi xav tau Vdj recombination?
Yuav ua li cas,Nws siv ob hom kev tiv thaiv kab mob loj, T hlwb thiab B hlwb (los yog, sib sau ua ke, lymphocytes).
Pom zoo:
Puas recombination tshwm sim hauv meiosis?
Recombination tshwm sim thaum ob lub molecules ntawm DNA pauv cov khoom ntawm lawv cov caj ces nrog ib leeg. Ib qho piv txwv tseem ceeb tshaj plaws ntawm kev sib koom ua ke tshwm sim thaum lub sij hawm meiosis (tshwj xeeb, thaum lub sij hawm prophase I), thaum homologous chromosomes kab hauv khub thiab sib pauv ntu ntawm DNA.
Somatic recombination tshwm sim nyob qhov twg?
Somatic recombination tshwm sim ua ntej kev sib cuag antigen, thaum lub sij hawm B cell loj hlob nyob rau hauv cov pob txha pob txha . Ib D H thiab ib J H yog randomly spliced nrog tshem tawm tag nrho cov intervening DNA (D-J koom). Tom ntej no, ib qho random V H ntu yog spliced rau qhov rov kho DJ H ntu.
Thaum twg pfizer tshwm sim tshwm sim?
Qee yam tshwm sim tshwm sim txoj cai tom qab koj txhaj tshuaj, zoo li mob me me hauv koj txhais caj npab. Lwm tus yuav siv sij hawm ntau teev los txhim kho. Nco ntsoov tias nrog ob koob tshuaj tiv thaiv zoo li Pfizer-BioNTech thiab Moderna, koj tuaj yeem pom muaj kev phiv ntau dua tom qab txhaj tshuaj thib ob.
Thaum twg qhov kev rov tshwm sim tshwm sim?
Thaum Replevin tuaj yeem thov Li no, qhov no yog qhov xwm txheej tshwm sim ntau tshaj plaws uas yuav tshwm sim thaum tus neeg siv khoom tsis raug them nyiaj qiv tsheb. Kev ua txhaum cai ntawm kev thaj yeeb nyab xeeb yog me ntsis luv luv. Nws tsis suav nrog kev txeeb tsheb yam tsis tau ceeb toom lossis kub xov tooj kom tsav tsheb mus.
Thaum qhov no yog qhov tshwm sim uas tshwm sim?
Lub hauv paus ntsiab lus ntawm kev mob Nrog qhov tshwm sim (uppada) ntawm qhov no, qhov tshwm sim. Thaum tsis muaj qhov no, qhov ntawd tsis tuaj. Nrog lub cessation (nirodha) ntawm no, uas ceases. - Samyutta Nikaya 12.61. Thaum qhov no yog qhov tshwm sim uas tshwm sim qhov tshwm sim uas tshwm sim thaum qhov no tsis yog qhov tsis yog qhov kev txiav txim siab tsis piav qhia?
