V(D)J recombination yuav nyiam tshwm sim hauv G1 theem ntawm lub voj voog ntawm tes. Cov kev sim tsis ntev los no nrog cov tshuaj tiv thaiv murine RAG2 qhia tias RAG2 protein ntau yog 20-fold ntau nyob rau hauv G1 cell voj voog theem dua li hauv S, G2, los yog M rau pre-B hlwb los yog thymocytes (Lin thiab Desiderio, 1994).
Vdj recombination tshwm sim theem twg?
V(D)J recombination yog lub tshuab ntawm somatic recombination uas tshwm sim tsuas yog hauv kev tsim cov lymphocytes thaum theem pib ntawm T thiab B cell maturation. Nws ua rau muaj ntau haiv neeg repertoire ntawm cov tshuaj tiv thaiv / immunoglobulins thiab T cell receptors (TCRs) pom nyob rau hauv B hlwb thiab T hlwb, feem.
Vdj recombination tshwm sim li cas?
VDJ recombination yog txheej txheem los ntawm uas T cells thiab B hlwb random sib sau ua ke cov noob sib txawv - paub tias sib txawv (V), ntau haiv neeg (D) thiab koom nrog (J) noob - txhawm rau tsim cov receptors tshwj xeeb (lub npe hu ua antigen receptors) uas tuaj yeem paub txog ntau hom molecule.
T cell somatic recombination tshwm sim nyob qhov twg?
Somatic recombination tshwm sim physiologically hauv sib dhos ntawm B cell receptor thiab T-cell receptor genes (V(D)J recombination), nrog rau hauv chav kawm hloov ntawm immunoglobulins. Somatic recombination kuj tseem ceeb hauv cov txheej txheem ntawm carcinogenesis.
Lub cev tiv thaiv kab mob dab tsi xav tau Vdj recombination?
Yuav ua li cas,Nws siv ob hom kev tiv thaiv kab mob loj, T hlwb thiab B hlwb (los yog, sib sau ua ke, lymphocytes).
