2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Somatic recombination tshwm sim ua ntej kev sib cuag antigen, thaum lub sij hawm B cell loj hlob nyob rau hauv cov pob txha pob txha . Ib DH thiab ib JH yog randomly spliced nrog tshem tawm tag nrho cov intervening DNA (D-J koom). Tom ntej no, ib qho random VH ntu yog spliced rau qhov rov kho DJH ntu.
Nyob rau hauv qhov chaw anatomical dab tsi ua cov txheej txheem ntawm somatic recombination hauv B hlwb tshwm sim?
Somatic recombination tshwm sim hauv cov pob txha pob txha (B hlwb) thiab thymus (T cells) thaum tsis muaj cov tshuaj tiv thaiv, piv txwv li, theem antigen- ywj pheej. Cov hlwb tshwj xeeb rau tib cov tshuaj tiv thaiv kuj raug tsim, piv txwv li, theem antigen-dependent.
Tus txheej txheem ntawm somatic recombination yog dab tsi?
Somatic recombination yog ib hom kev hloov pauv ntawm cov noob uas cells ntawm lub cev tiv thaiv kab mob lub cev txiav tawm cov cheeb tsam me me ntawm DNA thiab tom qab ntawd muab cov khoom seem ntawm DNA rov qab ua ke hauv txoj kev yuam kev.
Vdj recombination somatic recombination nyob qhov twg?
V(D)J recombination yog lub tshuab ntawm somatic recombination uas tshwm sim tsuas yog hauv txhim kho lymphocytes thaum ntxov ntawm T thiab B cell maturation.
Puas recombination tshwm sim hauv somatic hlwb?
Nws paub zoo tias nyob rau hauv mammalian somatic hlwb, mitotic recombination tshwm sim thiab tuaj yeem hloov kho los ntawm keeb kwm caj ces. Txawm li cas los xij, txheej txheem ntawmsomatic recombination tseem tsis to taub thiab nyuaj rau kev kawm hauv cov qauv siab dua.
Pom zoo:
Rau qhov tshwm sim tshwm sim?
Cov tshuaj tiv thaiv tus kheej yogtawm tsam uas nyiam tsim cov khoom ntawm cov xwm txheej uas tshwm sim. … Qhov kev sib xyaw ua ke ntawm kev txo qis ntawm lub zog thiab qhov nce hauv entropy txhais tau hais tias cov tshuaj tiv thaiv combustion tshwm sim tsis tu ncua.
Thaum twg vdj recombination tshwm sim?
V(D)J recombination yuav nyiam tshwm sim hauv G1 theem ntawm lub voj voog ntawm tes. Cov kev sim tsis ntev los no nrog cov tshuaj tiv thaiv murine RAG2 qhia tias RAG2 protein ntau yog 20-fold ntau nyob rau hauv G1 cell voj voog theem dua li hauv S, G2, los yog M rau pre-B hlwb los yog thymocytes (Lin thiab Desiderio, 1994).
Qhov kev tua ntawm qhov kev sib raug zoo tshwm sim nyob qhov twg?
Kev phom sij ntawm O.K. Corral yog 30-thib ob qhov kev sib tua ntawm cov neeg tsim cai lij choj coj los ntawm Virgil Earp thiab cov tswv cuab ntawm ib pawg neeg tawm tsam hu ua Cowboys suav nrog Ike Clanton uas tshwm sim thaum 3:00 teev tsaus ntuj.
Thaum twg qhov kev rov tshwm sim tshwm sim?
Thaum Replevin tuaj yeem thov Li no, qhov no yog qhov xwm txheej tshwm sim ntau tshaj plaws uas yuav tshwm sim thaum tus neeg siv khoom tsis raug them nyiaj qiv tsheb. Kev ua txhaum cai ntawm kev thaj yeeb nyab xeeb yog me ntsis luv luv. Nws tsis suav nrog kev txeeb tsheb yam tsis tau ceeb toom lossis kub xov tooj kom tsav tsheb mus.
Thaum qhov no yog qhov tshwm sim uas tshwm sim?
Lub hauv paus ntsiab lus ntawm kev mob Nrog qhov tshwm sim (uppada) ntawm qhov no, qhov tshwm sim. Thaum tsis muaj qhov no, qhov ntawd tsis tuaj. Nrog lub cessation (nirodha) ntawm no, uas ceases. - Samyutta Nikaya 12.61. Thaum qhov no yog qhov tshwm sim uas tshwm sim qhov tshwm sim uas tshwm sim thaum qhov no tsis yog qhov tsis yog qhov kev txiav txim siab tsis piav qhia?
