Somatic recombination tshwm sim ua ntej kev sib cuag antigen, thaum lub sij hawm B cell loj hlob nyob rau hauv cov pob txha pob txha . Ib DH thiab ib JH yog randomly spliced nrog tshem tawm tag nrho cov intervening DNA (D-J koom). Tom ntej no, ib qho random VH ntu yog spliced rau qhov rov kho DJH ntu.
Nyob rau hauv qhov chaw anatomical dab tsi ua cov txheej txheem ntawm somatic recombination hauv B hlwb tshwm sim?
Somatic recombination tshwm sim hauv cov pob txha pob txha (B hlwb) thiab thymus (T cells) thaum tsis muaj cov tshuaj tiv thaiv, piv txwv li, theem antigen- ywj pheej. Cov hlwb tshwj xeeb rau tib cov tshuaj tiv thaiv kuj raug tsim, piv txwv li, theem antigen-dependent.
Tus txheej txheem ntawm somatic recombination yog dab tsi?
Somatic recombination yog ib hom kev hloov pauv ntawm cov noob uas cells ntawm lub cev tiv thaiv kab mob lub cev txiav tawm cov cheeb tsam me me ntawm DNA thiab tom qab ntawd muab cov khoom seem ntawm DNA rov qab ua ke hauv txoj kev yuam kev.
Vdj recombination somatic recombination nyob qhov twg?
V(D)J recombination yog lub tshuab ntawm somatic recombination uas tshwm sim tsuas yog hauv txhim kho lymphocytes thaum ntxov ntawm T thiab B cell maturation.
Puas recombination tshwm sim hauv somatic hlwb?
Nws paub zoo tias nyob rau hauv mammalian somatic hlwb, mitotic recombination tshwm sim thiab tuaj yeem hloov kho los ntawm keeb kwm caj ces. Txawm li cas los xij, txheej txheem ntawmsomatic recombination tseem tsis to taub thiab nyuaj rau kev kawm hauv cov qauv siab dua.
