Ntxiv rau, txawm hais tias ib txwm mob myeloid hlwb thaum ntxov tsis qhia qhov chaw CD45RA, Mr isoform siab, malignant mob myeloid leukemia (AML) cov hlwb nquag qhia cov isoform no, nrog lossis nrog. - tawm CD45RO, qhov qis Mr isoform.
Puas yog CD45 ntawm myeloid cells?
Tsev neeg CD45 muaj protein ntau tyrosine phosphatase (PTPase) kev ua haujlwm thiab tau qhia nyob rau hauv ib lossis ntau dua ntawm nws cov isoforms ntawm tag nrho cov lymphohematopoietic hlwb. … Granulocytic, los yog myeloid, cell sib txawv yog nrog los ntawm ib tug xov tooj ntawm morphologic thiab immunophenotypic hloov.
Cov hlwb twg yog CD45 qhia rau?
CD45 antigen (leukocyte common antigen), ib qho tshwj xeeb thiab ubiquitous membrane glycoprotein nrog molecular mass txog 200 kDa, yog qhia rau yuav luag tag nrho cov hematopoietic hlwb tshwj tsis yog rau cov laus erythrocytes.
Lub cev tiv thaiv kab mob dab tsi nthuav qhia CD45?
CD45 noncovalently koom nrog hauv cheeb tsam transmembrane nrog LPAP (los yog lymphocyte phosphatase-associated phosphoprotein, tseem hu ua PTPRCAP, CD45-AP thiab LSM-1), 32-kD transmembrane protein qhia hauv T, B, NK cells , as well as hematopoietic progenitors91.
Puas yog cov kab mob tiv thaiv kab mob CD45+?
CD45 yog ib qho loj transmembrane glycoprotein qhia rau txhua lub hlwb nucleated hematopoietic. Yim isoforms ntawm CD45 yog faib los ntawm lub cev tiv thaiv kab mobraws li hom cell thiab qib ntawm kev sib txawv ntawm tes. … Hauv T cells, covsrc tsev neeg kinases, lck thiab fyn, yog cov neeg sib tw rau qhov kev tswj hwm kinase.
