Aminoglycosides tsis ua haujlwm tawm tsam anaerobes vim lawv uptake hla cov kab mob cell membranes nyob ntawm lub zog muab los ntawm aerobic metabolism. Yog li ntawd, lawv tau txo qis kev ua haujlwm hauv thaj chaw uas tsis muaj pH thiab oxygen nruj (piv txwv li, abscesses).
Vim li cas tsis aminoglycosides ua haujlwm ntawm anaerobes?
2 Lub zog xav tau rau aminoglycoside uptake mus rau hauv cov kab mob ntawm tes. Anaerobes muaj lub zog tsawg dua rau qhov kev nce no, yog li aminoglycosides tsis tshua muaj zog tiv thaiv anaerobes. Aminoglycosides yog absorbed tsis zoo los ntawm lub plab zom mov.
Dab tsi tiv thaiv aminoglycosides?
Qee hom kab mob Pseudomonas aeruginosa thiab lwm yam kab mob gram-negative bacillipom cov aminoglycoside tsis kam vim kev thauj mus los lossis cov membrane impermeabilization. Cov txheej txheem no zoo li chromosomally kho kom haum thiab ua rau muaj kev sib cuam tshuam rau tag nrho cov aminoglycosides.
Dab tsi ua rau aminoglycoside tsis kam?
Resistance to aminoglycosides yuav tshwm sim raws li ntau lub tswv yim: (1) enzymatic hloov kho thiab inactivation ntawm aminoglycosides , kho los ntawm aminoglycoside acetyltransferases, nucleotidyltransferases, los yog phosphotransferasesgram thiab nquag pom nyob rau hauv. -positive thiab -negative bacteria2, 3; (2) nce …
Vim li cas aminoglycosides tsis muab qhov ncauj?
Aminoglycosidesxws li gentamicin tsis tuaj yeem muab tshuaj rau qhov ncauj rau kev kho mob kab mob hauv lub cev vim tias lawv tsis nqus los ntawm lub plab zom mov tsis zoo [294].
