2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Aminoglycosides tshwm sim txhawm rau tsim cov dawb radicals hauv pob ntseg sab hauv, nrog rau kev puas tsuaj mus tas li rau cov hlwb thiab cov hlwb, ua rau tsis hnov lus mus tas li. Ob qhov kev hloov pauv hauv mitochondrial 12S ribosomal RNA noob tau raug tshaj tawm yav dhau los rau cov neeg nqa khoom mus rau aminoglycoside-induced ototoxicity.
Vim li cas Aminoglycosides ua rau nephrotoxicity?
Aminoglycosides yog nephrotoxic vim tias qhov me me tab sis loj ntawm cov tshuaj noj (≈5%) tau khaws cia rau hauv cov hlwb epithelial nyob rau hauv kab ntawm S1 thiab S2 ntu ntawm cov tubules proximal (135) tom qab glomerular pom.(30).
Cov tshuaj tua kab mob aminoglycoside ua rau lag ntseg li cas?
Hmoov tsis zoo, cisplatin thiab aminoglycosides muaj peev xwm ua rau hnov lus tsis hnov lus. Qhov no yog vim feem ntau yog los ntawm puas rau cov plaub hau sab nraud, pib hauv qhov basal tig ntawm cochlea.
Vim li cas cov tshuaj tua kab mob ua rau ototoxicity?
cov tshuaj paub zoo uas ua rau tsis hnov lus, kev kho mob hu ua "ototoxicity." Aminoglycosides yog cov tshuaj tua kab mob uas txo cov kab mob muaj peev xwm tsim cov proteins. Qhov no ua rau cov kab mob tsis muaj zog thiab txwv tsis pub kis tus kab mob.
gentamicin ua rau ototoxicity li cas?
Cov kev tshawb fawb pib qhia tias kev noj tshuaj gentamicin los ntawm pob ntseg sab hauv sai sai ua rau saturation tab sis cov tshuaj tsuas yog maj mam tso tawm. Nyob ntev raug ntawmcov plaub hau rau aminoglycoside yog qhov ua rau muaj kev puas tsuaj.
Pom zoo:
Vim li cas anaerobes tiv taus aminoglycosides?
Aminoglycosides tsis ua haujlwm tawm tsam anaerobes vim lawv uptake hla cov kab mob cell membranes nyob ntawm lub zog muab los ntawm aerobic metabolism. Yog li ntawd, lawv tau txo qis kev ua haujlwm hauv thaj chaw uas tsis muaj pH thiab oxygen nruj (piv txwv li, abscesses).
Vim li cas rau rau ntawm rau lub sigma?
Tus rau hauv Six Sigma yog hais txog qhov tseeb tias nws yuav siv rau qhov kev sib txawv rau tus qauv los ntawm qhov txhais tau tias ua yuam kev tshwm sim. Qhov no txhais rau 3.4 yuam kev tawm ntawm ib lab txheej xwm. Ib qho kev sib txawv me me yuav txhais tau tias qhov ua yuam kev ntau dua thiab qhov tsis txaus ntseeg ntawm qhov zoo.
Doxycycline puas ua rau ototoxicity?
Txoj Kev Siv Tshuaj Txhaum Tshuaj Ototoxicity Cov Tshuaj cuam tshuam nrog tinnitus suav nrog salicylates, quinine, streptomycin, neomycin, indomethacin, doxycycline, furosemide, hlau, thiab caffeine . Cov tshuaj tua kab mob dab tsi tuaj yeem ua rau ototoxicity?
Yuav ua li cas txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau pom kev pom?
Txawm li cas los xij, corneal collagen cross-linking - cov txheej txheem qib siab tau pom zoo los ntawm US Food and Drug Administration (FDA) hauv xyoo 2016 - tuaj yeem txhim kho qhov pom kev hauv cov neeg mob txhua hnub nyoog. Corneal collagen cross-linking (CXL) tsis yog kho rau keratoconus, tab sis nws tuaj yeem pab tiv thaiv tus mob kom tsis txhob mob hnyav.
Puas yog tshuaj aspirin ua rau ototoxicity?
Ntawm cov ntaub ntawv muaj txiaj ntsig zoo ntawm cov tshuaj aspirin yog qhov muaj peev xwm rau ototoxicity. Tinnitus thiab hnov lus tsis hnov lus, feem ntau thim rov qab, cuam tshuam nrog kev mob hnyav thiab kev tswj hwm lub sijhawm ntev ntawm salicylates.
