Aminoglycosides tshwm sim txhawm rau tsim cov dawb radicals hauv pob ntseg sab hauv, nrog rau kev puas tsuaj mus tas li rau cov hlwb thiab cov hlwb, ua rau tsis hnov lus mus tas li. Ob qhov kev hloov pauv hauv mitochondrial 12S ribosomal RNA noob tau raug tshaj tawm yav dhau los rau cov neeg nqa khoom mus rau aminoglycoside-induced ototoxicity.
Vim li cas Aminoglycosides ua rau nephrotoxicity?
Aminoglycosides yog nephrotoxic vim tias qhov me me tab sis loj ntawm cov tshuaj noj (≈5%) tau khaws cia rau hauv cov hlwb epithelial nyob rau hauv kab ntawm S1 thiab S2 ntu ntawm cov tubules proximal (135) tom qab glomerular pom.(30).
Cov tshuaj tua kab mob aminoglycoside ua rau lag ntseg li cas?
Hmoov tsis zoo, cisplatin thiab aminoglycosides muaj peev xwm ua rau hnov lus tsis hnov lus. Qhov no yog vim feem ntau yog los ntawm puas rau cov plaub hau sab nraud, pib hauv qhov basal tig ntawm cochlea.
Vim li cas cov tshuaj tua kab mob ua rau ototoxicity?
cov tshuaj paub zoo uas ua rau tsis hnov lus, kev kho mob hu ua "ototoxicity." Aminoglycosides yog cov tshuaj tua kab mob uas txo cov kab mob muaj peev xwm tsim cov proteins. Qhov no ua rau cov kab mob tsis muaj zog thiab txwv tsis pub kis tus kab mob.
gentamicin ua rau ototoxicity li cas?
Cov kev tshawb fawb pib qhia tias kev noj tshuaj gentamicin los ntawm pob ntseg sab hauv sai sai ua rau saturation tab sis cov tshuaj tsuas yog maj mam tso tawm. Nyob ntev raug ntawmcov plaub hau rau aminoglycoside yog qhov ua rau muaj kev puas tsuaj.
