2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Piedmontese myostatin ib ntus muaj qhov tsis zoo ntawm kev hloov pauv hauv exon 3, ua rau muaj kev hloov pauv ntawm tyrosine rau cov cysteine invariant hauv thaj tsam ntawm cov protein.
Dab tsi ntawm kev hloov pauv hauv DNA los ntawm Piedmontese uas tuaj yeem ua rau cov leeg nqaij hypertrophy?
The Piedmontese MSTN missense mutation G938A yog txhais rau C313Y myostatin protein. Qhov kev hloov pauv no hloov MSTN ua haujlwm raws li qhov tsis zoo ntawm cov leeg nqaij loj hlob, yog li ua rau cov leeg nqaij hypertrophy. MiRNAs tuaj yeem ua lub luag haujlwm hauv skeletal leeg hypertrophy modulation los ntawm down-regulating gene expression.
Hom kev hloov pauv twg tshwm sim hauv cov noob rau myostatin?
Tsawg kawg ib qho kev hloov pauv hauv MSTN noob tau pom tias ua rau myostatin-hais txog cov leeg nqaij hypertrophy, ib qho mob tsis tshua muaj tshwm sim los ntawm cov leeg nqaij thiab lub zog. Kev hloov pauv, uas tau sau ua IVS1 + 5G>A, cuam tshuam txoj kev cov noob cov lus qhia siv los ua myostatin.
Yuav ua li cas hloov pauv yog ob leeg muscling?
Ob leeg muscling yog lo lus siv los xaiv cov leeg nqaij hypertrophy yam ntxwv ntawm nyuj thiab Texel yaj. Nws yog vim hloov pauv hauv myostatin (MSTN) gene, uas encodes qhov kev loj hlob- tswj hwm myostatin. Cov leeg nqaij hypertrophy tshwm sim los ntawm kev nce tag nrho cov fibers.
Kev hloov pauv yam twg tshwm sim hauv Belgian Blue myostatin?
ob leeg muscling (ncenqaij pob txha) yog ib tug yam ntxwv pom nyob rau hauv ib hom nyuj hu ua Belgian Blue. Cov yam ntxwv ntawm ob leeg muscling tau taug qab mus rau ib leeg, autosomal, noob hloov, ua rau kaum ib khub kev tshem tawm hauv myostatin gene. Qhov no ua rau cov protein tsis ua haujlwm tau ua.
Pom zoo:
Dab tsi yog qhov hloov pauv thiab hloov pauv hloov pauv?
Point mutations hloov ib leeg nucleotide. Frameshift kev hloov pauv yog ntxiv lossis tshem tawm ntawm nucleotides uas ua rau muaj kev hloov pauv hauv kev nyeem ntawv. frameshift thiab point mutation yog dab tsi? Ib qho kev hloov pauv cuam tshuam rau ib khub hauv paus.
Qhov kev hloov pauv no puas yuav ua rau muaj kev hloov pauv hloov pauv?
Yog li, yog tias muaj kev hloov pauv, piv txwv li, kev ntxig lossis tshem tawm ntawm nucleotide, tshwm sim, qhov no tuaj yeem ua rau kev hloov pauv ntawm kev nyeem ntawv. Nws hloov tag nrho cov amino acid ib ntus. Cov kev hloov pauv no yog hu ua frameshift mutation (tseem hu ua kev nyeem ntawv hloov pauv, nyeem ntawv hloov pauv, lossis framing yuam kev).
Qhov twg yog qhov kev hloov pauv hloov pauv hloov pauv?
Semiconservative replication piav qhia txog cov txheej txheem ntawm DNA replication nyob rau hauv tag nrho cov paub hlwb. DNA replication tshwm sim ntawm ntau lub hauv paus pib ntawm kev rov ua dua raws DNA qauv strand. Raws li DNA ob chav helix yog unwound by helicase, replication tshwm sim nyias ntawm txhua tus qauv strand nyob rau hauv antiparallel cov lus qhia.
Qhov kev hloov pauv twg yog xav tias yuav cuam tshuam los ntawm kev hloov pauv hloov pauv?
Dependent Variable Qhov sib txawv uas nyob ntawm lwm yam uas ntsuas. Cov kev hloov pauv no yuav tsum tau hloov pauv raws li qhov kev sim ua haujlwm ntawm tus kheej hloov pauv lossis hloov pauv. Nws yog cov nyhuv presumed. Qhov kev tshawb fawb hloov pauv twg yog qhov tshwm sim?
Los ntawm kev hloov pauv hloov pauv hloov pauv?
Kev hloov pauv hloov pauv hloov pauv (TMA) yog qhov isothermal (tsis hloov pauv nucleic acid kub), ib leeg-tube nucleic acid amplification system siv ob lub enzymes, RNA polymerase thiab thim rov qab kev sau ntawv. … Cov txheej txheem no tuaj yeem siv los tsom rau RNA thiab DNA.
