Piedmontese myostatin ib ntus muaj qhov tsis zoo ntawm kev hloov pauv hauv exon 3, ua rau muaj kev hloov pauv ntawm tyrosine rau cov cysteine invariant hauv thaj tsam ntawm cov protein.
Dab tsi ntawm kev hloov pauv hauv DNA los ntawm Piedmontese uas tuaj yeem ua rau cov leeg nqaij hypertrophy?
The Piedmontese MSTN missense mutation G938A yog txhais rau C313Y myostatin protein. Qhov kev hloov pauv no hloov MSTN ua haujlwm raws li qhov tsis zoo ntawm cov leeg nqaij loj hlob, yog li ua rau cov leeg nqaij hypertrophy. MiRNAs tuaj yeem ua lub luag haujlwm hauv skeletal leeg hypertrophy modulation los ntawm down-regulating gene expression.
Hom kev hloov pauv twg tshwm sim hauv cov noob rau myostatin?
Tsawg kawg ib qho kev hloov pauv hauv MSTN noob tau pom tias ua rau myostatin-hais txog cov leeg nqaij hypertrophy, ib qho mob tsis tshua muaj tshwm sim los ntawm cov leeg nqaij thiab lub zog. Kev hloov pauv, uas tau sau ua IVS1 + 5G>A, cuam tshuam txoj kev cov noob cov lus qhia siv los ua myostatin.
Yuav ua li cas hloov pauv yog ob leeg muscling?
Ob leeg muscling yog lo lus siv los xaiv cov leeg nqaij hypertrophy yam ntxwv ntawm nyuj thiab Texel yaj. Nws yog vim hloov pauv hauv myostatin (MSTN) gene, uas encodes qhov kev loj hlob- tswj hwm myostatin. Cov leeg nqaij hypertrophy tshwm sim los ntawm kev nce tag nrho cov fibers.
Kev hloov pauv yam twg tshwm sim hauv Belgian Blue myostatin?
ob leeg muscling (ncenqaij pob txha) yog ib tug yam ntxwv pom nyob rau hauv ib hom nyuj hu ua Belgian Blue. Cov yam ntxwv ntawm ob leeg muscling tau taug qab mus rau ib leeg, autosomal, noob hloov, ua rau kaum ib khub kev tshem tawm hauv myostatin gene. Qhov no ua rau cov protein tsis ua haujlwm tau ua.
