Yog tias muaj ib qho qub thiab ib qho txawv txav ntawm ib qho chaw tshwj xeeb, raws li pom nyob rau hauv ib qho kab mob autosomal dominant cancer susceptibility disorder, poob ntawm ib txwm allele ua ib locus nrog noib txwm muaj nuj nqi.
LOH yog dabtsi?
Kev poob ntawm heterozygosity (LOH) yog ib qho xwm txheej tshwm sim hauv caj ces hauv kev txhim kho mob qog noj ntshav, thiab paub tias muaj kev koom tes hauv kev poob ntawm cov tsiaj qus-hom alleles hauv ntau yam mob qog noj ntshav..
LOH ua rau mob qog noj ntshav li cas?
Kev poob ntawm heterozygosity (LOH) yog hais txoghom kev hloov pauv caj ces thaum lub sijhawm uas muaj qhov poob ntawm ib qho qauv ntawm cov noob lossis ib pawg ntawm cov noob. Qee zaum, kev poob ntawm heterozygosity tuaj yeem ua rau muaj mob qog noj ntshav.
Koj ua li cas txiav txim siab heterozygosity poob?
Kev poob ntawm heterozygosity tuaj yeem txheeb pom hauv cov qog nqaij hlav los ntawm ceeb toom qhov muaj heterozygosity ntawm cov caj ces hauv cov kab mob hauv cov kab mob DNA, thiab tsis muaj heterozygosity ntawm qhov chaw nyob hauv cov qog nqaij hlav. cells.
LOH tshwm sim qhov twg?
LOH tshwm sim thaum kab mob qog noj ntshav uas yog keeb kwm heterozygous ntawm ib qho chaw poob ib qho ntawm nws ob lub alleles ntawm qhov ntawdlocus, los ntawm kev tshem tawm ntawm ib qho allele (copy-loss LOH), lossis los ntawm kev tshem tawm ntawm ib qho allele nrog rau qhov sib npaug ntawm cov allele (copy-neutral LOH).
