Yog muaj ib qho qub thiab ib qho txawv txav ntawm ib qho chaw tshwj xeeb, raws li tau pom nyob rau hauv ib qho kev cuam tshuam ntawm autosomal dominant cancer susceptibility disorder, poob ntawm ib txwm allele ua ib qho chaw. tsis muaj kev ua haujlwm li qub.
Yuav poob heterozygosity tshwm sim li cas?
Kev poob ntawm heterozygosity (LOH) txhais tau tias yog kev poob ntawm ib tus niam txiv txoj kev koom tes hauv lub xovtooj, tuaj yeem tshwm sim los ntawm ncaj qha rho tawm, tshem tawm vim kev hloov pauv tsis tu ncua, hloov pauv noob, mitotic recombination, lossis poob ntawm chromosome (monsomy).
Yuav ua li cas paub yog tias koj poob heterozygosity?
Kev poob ntawm heterozygosity tuaj yeem txheeb pom hauv cov qog nqaij hlav los ntawm ceeb toom qhov muaj heterozygosity ntawm cov caj ces hauv cov kab mob hauv cov kab mob DNA, thiab tsis muaj heterozygosity ntawm qhov chaw nyob hauv cov qog nqaij hlav. cells.
Dab tsi ua rau poob ntawm heterozygosity hauv qog noj ntshav?
Kev poob ntawm heterozygosity (LOH) hauv kev mob qog noj ntshav feem ntau tshwm sim los ntawm luam cov lej hloov pauv (CNAs) uas tuaj yeem hloov ntau ntau mus rau txhiab tus noob hauv cov kab mob qog noj ntshav 9 , 10. Feem ntau LOH yog vim nruj daim ntawv-poob (copy-lossis LOH), qhov twg allelic poob tshwm sim nyob rau hauv cov ntsiab lus ntawm ib tug txo nyob rau hauv gene luam naj npawb.
Yuav ua li cas pom thaum qhov poob ntawm heterozygosity?
Kev poob ntawm heterozygosity (LOH) yog hais txog ib hom kev hloov pauv caj ces thaum lub sijhawm muaj qhov poob ntawm ib qho qauv ntawm cov noob lossis ib pawg ntawm cov noob. HauvQee qhov xwm txheej, kev poob ntawm heterozygosity tuaj yeem ua rau muaj mob qog noj ntshav.
