Qhov PKC ubiquitination thiab degradation yog tiv thaiv los ntawm inhibition ntawm PKC ua kom pom thawj zaug uas Ser / Thr protein kinase nthuav tawm ua kom muaj protein ntau degradation (25), uas ua raws li kev tawm tswv yim tswj kev tswj hwm.
Dab tsi ua rau cov protein degradation?
Proteins raug cim rau kev degradation los ntawm qhov txuas ntawm ubiquitin rau cov amino pawg ntawm cov saw ntawm cov lysine residue. Tom qab ntawd ntxiv ubiquitins ntxiv los ua ib txoj hlua multiubiquitin. Xws li cov protein ntau polyubiquinated tau lees paub thiab degraded los ntawm qhov loj, multisubunit protease complex, hu ua proteasome.
Kinases ua li cas rau cov protein?
Protein kinases thiab phosphatase yog enzymes catalysing hloov pauv ntawm phosphate ntawm lawv cov substrates. Ib qho protein kinase catalyses hloov pauv ntawm -phosphate los ntawm ATP (lossis GTP) mus rau nws cov protein substrates thaum cov protein phosphatase catalyses hloov cov phosphate los ntawm phosphoprotein mus rau cov dej molecule.
Yuav ua li cas enzyme yog lub luag haujlwm rau degradation ntawm cov protein?
Proteolysis yog kev tawg ntawm cov proteins rau hauv me me polypeptides lossis amino acids. Uncatalysed, hydrolysis ntawm peptide bonds qeeb heev, siv ntau pua xyoo. Proteolysis feem ntau yog catalysed los ntawm cellular enzymes hu ua proteases, tab sis kuj tuaj yeem tshwm sim los ntawm kev zom zaub mov.
Yuav ua li cas thaum cov protein kinase tau qhib?
Protein kinase A koom nrognyob rau hauv 'sib ntaus los yog ya' teb nyob rau hauv cov tsiaj. Hauv cov lus teb no, hormone adrenaline ua rau kev tsim cov cAMP, tus xa xov thib ob. cAMP ces activates protein kinase A. Protein kinase A ces activates phosphorylase kinase uas txuas ntxiv txoj hauv kev rau kev tawg ntawm glycogen.
