2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Stromal cells - tseem hu ua mesenchymal stem cells (MSCs) - yog non-hematopoietic, ntau lub zog, lub hlwb rov ua dua tshiab uas muaj peev xwm ntawm trilineage sib txawv (mesoderm, ectoderm, thiab endoderm).
Puas yog mesenchymal stem cells?
Mesenchymal stem cells (MSCs) yog ntau lub qia hlwb pom nyob rau hauv cov pob txha uas yog ib qho tseem ceeb rau kev tsim thiab kho cov pob txha pob txha, xws li pob txha mos, pob txha thiab cov rog pom hauv pob txha. mob plab. Cov no tsis yog yuav tsum tsis meej pem nrog heematopoietic (ntshav) qia hlwb uas tseem muaj nyob hauv cov pob txha thiab ua rau peb cov ntshav.
Mesenchymal stromal cell yog dab tsi?
Mesenchymal stromal cells (MSCs) yog cov ntxaiv zoo li cov yas-adherent hlwb cais tawm ntawm cov pob txha, adipose, thiab lwm cov ntaub so ntswg, nrog ntau lub peev xwm sib txawv hauv vitro. … MSCs tau piav qhia thawj zaug los ntawm Friendenstein ua cov hlwb txhawb nqa hematopoietic ntawm cov pob txha pob txha.
Qhov txawv ntawm stromal cells thiab qia hlwb yog dab tsi?
Lub sij hawm pob txha pob txha stromal cell yog siv rau cov uas tsis yog-hemopoitic connective cov ntaub so ntswg / cell ntawm mesenchymal keeb kwm uas yog originated nyob rau hauv cov pob txha pob txha. Yog hais tias ib tug stromal cell muaj stem cell khoom ces nws hu ua stromal qia cell.
Kev ua haujlwm ntawm mesenchymal stromal cells yog dab tsi?
Mesenchymal qia hlwb (MSCs) muaj ntau lub luag haujlwm hauv lub cev thiab cellular ib puag ncig, thiab cov cellular phenotypes ntawm MSCs hloov hauvtxawv tej yam kev mob. MSCs txhawb nqa kev saib xyuas ntawm lwm lub hlwb, thiab lub peev xwm ntawm MSCs sib txawv rau ntau hom cell ua rau cov hlwb tshwj xeeb thiab muaj peev xwm ua tau.
Pom zoo:
Puas yog cov kab mob mononuclear qia hlwb?
MNCs yog cov neeg laus qia hlwb uas muaj feem ntawm cov hlwb hauv cov pob txha (BM-MNCs) lossis cov ntshav peripheral (PB-MNCs) uas tsis muaj granules hauv lawv cov cytoplasm thiab muaj ib lub hauv paus nucleus. Puas yog qia hlwb mononuclear?
Puas yog hematopoietic qia hlwb pluripotent?
Hematopoietic stem cells yog pluripotent thiab tsis yog "hematopoietic" Blood Cells Mol Dis. Puas yog hematopoietic qia hlwb pluripotent lossis multipotent? Hematopoietic stem cells (HSCs) yog immature multipotent neeg laus qia cov hlwb uas ua rau tag nrho cov qe ntshav loj hlob tuaj, ua kom pom kev mus sij hawm ntev, thiab muaj peev xwm ua kom rov ua tau zoo dua.
Yuav ua li cas rho tawm mesenchymal qia hlwb?
Mesenchymal Stem Cell Isolation los ntawm Umbilical Cord Tshuaj qaum (UCs) hauv cov tshuaj hypochlorite (1:3). Yuav UCs nrog PBS. Tau UCs hauv 10% FBS / DMEM-qabzib tsawg txog li 12 teev. Tshuaj UCs peb zaug nrog PBS. Txhaj cov leeg thiab cov hlab ntsha nrog 3mL 0.
Puas yog mesenchymal hlwb osteogenic hlwb?
Mesenchymal qia hlwb cog lus rau osteogenic kab thiab sib txawv rau hauv cov laus osteoblasts thiab osteocytes osteocytes Osteocytes yog cov hlwb nyob hauv cov pob txha nws tus kheej thiab yog 'entrapped' osteoblasts . Lawv yog cov post-proliferative, sawv cev rau cov neeg paub tab sib txawv tshaj plaws ntawm cov kab mob osteoblast.
Mesenchymal stromal cells yog dab tsi?
Mesenchymal stromal cells (MSCs) yog cov ntxaiv zoo li cov yas-adherent hlwb cais tawm ntawm cov pob txha, adipose, thiab lwm cov ntaub so ntswg, nrog ntau lub peev xwm sib txawv hauv vitro. … MSCs tau piav qhia thawj zaug los ntawm Friendenstein ua cov hlwb txhawb nqa hematopoietic ntawm cov pob txha pob txha.
