Insurmountable antagonism yog hais txog kev sim uas qhov kev npaj receptor yog preincubated nrog tus antagonist ua ntej kev tswj hwm ntawm agonist thiab kev ntsuas ntawm cov lus teb(raws li nyob rau hauv feem ntau classical organ da dej thwmsim).
receptor antagonism txhais li cas?
A receptor antagonist yog hom receptor ligand lossis tshuaj uas thaiv lossis ua kom cov lus teb lom neeg los ntawm kev khi rau thiab thaiv cov receptor ntau dua li ua komnws zoo li tus agonist. Cov tshuaj antagonist cuam tshuam rau kev ua haujlwm ntawm cov receptor proteins.
Kev sib tw antagonism nrog piv txwv yog dab tsi?
Antagonists. … Muaj ob hom kev tawm tsam: kev sib tw (reversible, surmountable) thiab tsis-competitive (irreversible, insurmountable). Piv txwv li, naloxoneyog qhov sib tw antagonists ntawm tag nrho cov opioid receptors thiab ketamine yog tus tsis sib tw antagonist ntawm NMDA-glutamate receptor.
Yuav ua li cas hauv kev sib tw antagonism?
Ib tug neeg sib tw antagonist khi rau tib lub xaib raws li tus agonist tab sis tsis qhib nws, yog li thaiv tus agonist qhov kev txiav txim. Ib tug tsis sib tw antagonist khi rau ib qho chaw allosteric (non-agonist) ntawm lub receptor los tiv thaiv kev ua kom cov receptor.
Dab tsi yog tshuaj tiv thaiv kab mob?
Pharmacological antagonist khi rau tib lub receptor raws li tus agonist ua. Nws occupies qhov chaw khi ntawm receptor thiabtiv thaiv kev khi ntawm agonist mus rau receptor. Nyob rau hauv txoj kev no, nws tiv thaiv kev ua kom lub receptor. Cov no suav nrog receptor blockers xws li alpha-blockers, beta-blockers, thiab lwm yam.
