Lub aorta-gonad-mesonephros (AGM) yog thaj tsam ntawm embryonic mesodermuas tsim thaum lub sij hawm embryonic kev loj hlob los ntawm para-aortic splanchnopleura nyob rau hauv qaib, nas thiab tib neeg embryos.
HSCs txhim kho nyob rau hauv lub cev qhov twg?
Lub cheeb tsam aorta–gonad–mesonephros (AGM)yog qhov chaw muaj zog hematopoietic nyob rau hauv lub cev ntawm tus tsiaj lub cev, thiab thawj qhov chaw ntawm cov kab mob hematopoietic qia hlwb (HSCs) tshwm sim.
Hemangioblasts tuaj qhov twg?
Hemangioblasts tau xav tias yog cov hlwb ntxov tshaj plaws rau hematopoiesis thiab vasculogenesis. Lawv tau tshaj tawm los ntawm embryonic qia hlwb (ESCs)thiab tuaj yeem muab tau hauv vitro los ntawm lub cev embryoid.
Dab tsi yog qhov tseeb hematopoiesis?
Txoj hematopoiesis tsim cov kab mob hematopoietic qia / progenitor cells (HSPCs) uas ua rau tag nrho cov ntshav paub tab thiab lub cev tiv thaiv kab mob, tab sis tseem txhais tsis zoo rau tib neeg. Ntawm no, peb daws cov tib neeg hematopoietic pej xeem nyob rau theem ntxov hematopoiesis los ntawm ib leeg-cell RNA-seq.
Kev ua haujlwm ntawm hematopoiesis yog dab tsi?
Hematopoiesis yog kev tsim tawm ntawm tag nrho cov cellular Cheebtsam ntawm cov ntshav thiab cov ntshav plasma. Nws tshwm sim nyob rau hauv lub hematopoietic system, uas muaj xws li cov kabmob thiab cov ntaub so ntswg xws li cov pob txha pob txha, daim siab, thiab tus po. Yooj yim, hematopoiesis yog cov txheej txheem uas lub cev tsim cov qe ntshav.
