Metabolism ntawm carcinogens tshwm sim hauv ntau cov ntaub so ntswg thoob plaws lub cev (ADMET Screen). … Nws yog dav ntseeg tias txoj hauv kev tseem ceeb hauv metabolic cuam tshuam nrog oxidation ntawm benzo[a]pyrene los ntawm cytochrome P450 (P450) rau ib qho epoxide.
Cov kab mob carcinogens ua haujlwm hauv koj lub cev li cas?
A carcinogen yog ib yam tus neeg muaj peev xwm ua rau mob qog noj ntshav rau tib neeg. Carcinogens tej zaum yuav yog ntuj, xws li aflatoxin, uas yog tsim los ntawm ib tug fungus thiab tej zaum kuj pom nyob rau hauv khaws cia nplej, los yog manmade, xws li asbestos los yog haus luam yeeb. Carcinogens ua haujlwm los ntawm kev cuam tshuam nrog lub cell DNA thiab inducing genetic mutations.
Cov kab mob carcinogens piav qhia dab tsi?
Ib yam mob qog noj ntshav ib yam uas ua rau koj mob qog noj ntshav. Tej zaum nws yuav yog ib yam khoom nyob rau hauv cov huab cua, ib yam khoom uas koj siv, los yog ib tug tshuaj nyob rau hauv cov zaub mov thiab dej qab zib.
Yuav ua li cas yog carcinogen?
Ntau cov carcinogens raug suav hais tias yog procarcinogens uas yuav tsum tau metabolic ua kom tawm dag zoglawv cov teebmeem genotoxic (4). Oxidative activation ntawm carcinogens los ntawm P450 enzymes ua rau tsim cov electrophilic reactive intermediates uas tuaj yeem khi rau DNA, ua rau cov DNA adducts uas yuav ua rau muaj kev hloov pauv (5)..
Dab tsi yog carcinogens thiab lawv cuam tshuam DNA li cas?
Carcinogens yog cov khoom uas ua rau muaj kev hloov pauv hauv DNA uas ua rau kev loj hlob ntawm cov qog nqaij hlav cancer. Carcinogens tuaj yeem raug cais raws li lub cev carcinogens, xws liRaws li ionizing hluav taws xob los yog ultraviolet lub teeb, los yog tshuaj carcinogens, xws li asbestos los yog cov khoom ntawm cov luam yeeb.
