PLP ua raws li coenzyme hauv txhua qhov kev hloov pauv, thiab hauv qee qhov decarboxylation, deamination, thiab racemization tshwm sim ntawm amino acids. Cov pab pawg aldehyde ntawm PLP tsim ib qho kev sib txuas ntawm Schiff-base (sab hauv aldimine) nrog ε-amino pawg ntawm ib pawg lysine tshwj xeeb ntawm aminotransferase enzyme.
YPLP hauv amino acid metabolism yog dab tsi?
Tus coenzyme pyridoxal phosphate (feem ntau luv luv PLP) yog daim ntawv nquag ntawm vitamin B6, lossis pyridoxine. PLP yog xav tau rau ntau tshaj 100 qhov sib txawv ntawm tib neeg cov metabolism, feem ntau nyob rau hauv ntau yam amino acid biosynthetic thiab degradation pathways.
PLP nyob ntawm enzymes yog dab tsi?
PLP-dependent enzymes catalyze ntau ntau hom tshuaj tiv thaiv thiab feem ntau muaj kev txuag lysine residue hauv qhov chaw ua haujlwm rau PLP khi. … Cov enzymes no koom nrog cov amino acid metabolism thiab tsim cov amino acid-derived metabolites.
Qhov twg amino acid puas PLP cofactor khi rau hauv qhov chaw nquag ntawm aminotransferases?
Pyridoxin, pyridoxal thiab pyridoxamine ua raws li cov vitamins (vitamin B 6) thiab hloov mus rau PLP. PLP yog cov cofactor ntawm aminotransferases thiab amino acid decarboxylase uas ua lub luag haujlwm tseem ceeb hauv cov metabolism hauv cov tshuaj nitrogenous. Nws yog covalently, txawm tias thim rov qab, khi rau lysine ntawm lub chaw nquag.
Yuav ua li casthaum transamination?
Kev hloov pauv yog txheej txheem los ntawm uas cov amino pawg tau raug tshem tawm ntawm cov amino acids thiab hloov mus rau qhov lees txais keto-acids los tsim cov amino acid version ntawm keto-acid thiab keto-acid version ntawm thawj. amino acid
