Malonate yog kev sib tw inhibitor ntawm enzyme succinate dehydrogenase: malonate khi rau qhov chaw nquag ntawm cov enzyme yam tsis muaj kev cuam tshuam, thiab yog li sib tw nrog succinate, ib txwm muaj substrate ntawm enzyme. … Cov tshuaj malonate decreases cellular respiration.
Malonate inhibit qhov tsim ntawm fumarate los ntawm succinate li cas?
Tus inhibitor muaj qhov zoo sib xws rau cov txheej txheem ib txwm muaj rau cov enzyme, thiab sib tw nrog nws rau qhov chaw nquag. … Ib qho piv txwv yooj yim ntawm qhov no suav nrog malonate ions inhibiting enzyme succinate dehydrogenase. Qhov no enzyme catalyses hloov pauv ntawm succinate ions rau fumarate ions.
malonate inhibit SDH li cas?
Malonate, kev sib tw inhibitor ntawm SDH, kuj tau pom tias tsim cov poov tshuaj tam sim no ua rau mitochondrial matrix o (ib qho txiaj ntsig ntawm mitochondrial K ATPchannel ua haujlwm) thiab yog inhibited los ntawm ATP thiab 5-HD (20). Tsis tas li ntawd, kev sib txuas ntawm caj ces ntawm KATP channel thiab SDH tau thov (21).
Lub xub ntiag ntawm malonate cuam tshuam li cas cov tshuaj tiv thaiv nrog succinate dehydrogenase?
Malonate yog qhov thim rov qab inhibitor ntawm succinate dehydrogenase. Succinate dehydrogenase plays lub luag haujlwm tseem ceeb hauv lub voj voog tricarboxylic acid thiab ua ib feem ntawm complex II ntawm electron thauj saw. … Txhob nrog succinate thaiv covCov kab mob, vim nws cov txiaj ntsig ntawm succinate dehydrogenase (Greene li al. 1993).
Yuav ua li cas yog tias succinate dehydrogenase inhibited?
Ib qho tsis ua tiav ntawm succinate dehydrogenase kev ua haujlwm yuav cuam tshuam cov hluav taws xob ntws mus rau ob qho tib si ua pa txoj kab III thiab lub pas dej quinone, ua rau muaj kev ntxhov siab loj oxidative paub los txhawb cov qog tsim hauv tib neeg..