Neurofibrillary tangles yog insoluble twisted fibers pom hauv lub hlwb hlwb. Cov tangles no feem ntau yog cov protein hu ua tau, uas yog ib feem ntawm cov qauv hu ua microtubule.
Cov plaques thiab tangles nyob qhov twg?
Qhov txawv ntawm cov plaques thiab tangles nyob hauv lawv cov qauv thiab cuam tshuam rau cov paj hlwb hauv cov ntaub so ntswg hauv hlwb. Amyloid plaques yog pawg uas tsim nyob rau hauv qhov chaw nruab nrab ntawm cov paj hlwb, whereas cov neurofibrillary tangles yog ib pob ntawm lub hlwb hlwb.
Ntaus neurofibrillary tangles tshwm sim li cas?
Neurofibrillary tangles yog tsim los ntawm hyperphosphorylation ntawm microtubule-txuas nrog cov protein hu ua tau, ua rau nws sib sau ua ke, lossis pab pawg, hauv daim ntawv tsis txaus. (Cov kev sib sau no ntawm hyperphosphorylated tau protein kuj tseem hu ua PHF, lossis "paired helical filaments").
Dab tsi yog neurofibrillary tangles hauv lub hlwb?
Neurofibrillary tangles yog kev sib txuam ntawm cov protein hu ua tau uas sau rau hauv cov neurons. Kev noj qab haus huv neurons, ib feem, tau txais kev txhawb nqa sab hauv los ntawm cov qauv hu ua microtubules, uas pab qhia cov as-ham thiab molecules ntawm lub cev ntawm tes mus rau axon thiab dendrites.
Qhov twg tau protein synthesis neurofibrillary tangles hauv Alzheimer's disease?
Tau kev hloov pauv pom hauv frontotemporal dementia tuaj yeem ua rau neurodegenerationlos ntawm kev txhawb nqa qhov txawv txav hyperphosphorylation ntawm tau . AD P- tau self-assembles into PHF/SF, forming neurofibrillary tangles . Tau truncation pom nyob rau hauv AD hlwb txhawb nqa nws tus kheej-assembly rau hauv PHF/SF.
