Neurofibrillary tangles (NFTs) yog ib txwm muaj nyob rau hauv AD autopsy specimens. Lawv tag nrho ua los ntawm microtubule-txuas nrog cov protein tau, uas, thaum hyperphosphorylated, tsim cov aggregates insoluble uas tuaj yeem sau tag nrho qhov chaw intracellular ntawm cov neuron.
Puas yog neurofibrillary tangles intracellular lossis extracellular?
Cov kab mob ntawm AD yog qhov tshwj xeeb los ntawm extracellular senile plaques thiab intracellular neurofibrillary tangles [31, 32]. Lub xub ntiag ntawm amyloid nyob rau hauv senile plaques thiab nyob rau hauv cerebral hlab ntsha (amyloid angiopathy) tau ntev lawm pathologically lees paub.
Ntaus neurofibrillary tangles nyob qhov twg?
Neurofibrillary tangles yog insoluble twisted fibers pom hauv lub hlwb hlwb. Cov tangles no feem ntau yog cov protein hu ua tau, uas yog ib feem ntawm cov qauv hu ua microtubule.
Puas yog neurofibrillary tangles hauv cov neurons?
Neurofibrillary tangles yog kev sib txuam ntawm cov protein hu ua tau uas sau rau hauv cov neurons. Kev noj qab haus huv neurons, ib feem, tau txais kev txhawb nqa sab hauv los ntawm cov qauv hu ua microtubules, uas pab qhia cov as-ham thiab molecules ntawm lub cev ntawm tes mus rau axon thiab dendrites.
Koj puas pom neurofibrillary tangles ntawm MRI?
MRI cov kev tshawb fawb tau pom cov qauv ntawm atrophy uas zoo li sib haum rau kev nce qib ntawm NFTs hauv cov ncauj lus nrog AD, nrog rau thaum ntxovKev koom tes ntawm qhov nruab nrab ntawm lub ntsej muag lub ntsej muag,2, 3 thiab ntau dua qhov kev poob qis ntawm neocortical raws li kev kawm nce qib.
