2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
HIV kho tsis tau, tab sis feem ntau tswj tau. Kev kho nrog nucleoside/nucleotide thim rov qab transcriptase inhibitors (NRTIs) yog ib txoj hauv kev los pab tiv thaiv tus kab mob los ntawm kev rov ua dua thiab tswj kev kis kab mob HIV.
Puas thim rov qab transcriptase inhibitors kho HIV?
Reverse transcriptase inhibitors yog tshuaj siv hauv kev tswj thiab kho tus kab mob HIV. Nws yog nyob rau hauv cov tshuaj tiv thaiv kab mob.
Vim li cas tus thim rov qab transcriptase inhibitor yuav zoo rau kev kho HIV?
Reverse transcriptase inhibitors yog nquag tawm tsam HIV, tus kab mob retrovirus. Cov tshuaj inhibit RNA tus kab mob replication los ntawm reversible inhibition ntawm tus kab mob HIV reverse transcriptase, uas thim rov qab transcribes tus kab mob RNA rau hauv DNA rau kev nkag mus rau hauv tus tswv tsev DNA sib lawv liag (saib daim duab 51.6).
HIV kho lossis kho li cas?
tshuaj HIV hu ua antiretroviral therapy (ART). Tsis muaj kev kho mob HIV. Tab sis nrog kev kho mob kom raug, koj tuaj yeem tswj tau HIV. Cov neeg feem coob tuaj yeem kis tus kab mob los ntawm kev tswj tsis pub dhau rau lub hlis.
Vim li cas cov neeg thim rov qab transcriptase inhibitors pab tiv thaiv kab mob HIV hauv cov tib neeg tsis muaj kab mob?
Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
NRTIs thaiv ib qho enzyme ntawm tus kab mob HIV hu ua reverse transcriptase uas tso cai rau HIV kis rau tib neeg lub hlwb, tshwj xeeb yog CD4 T hlwb lossis lymphocytes. Rov qab transcriptase convertsHIV genetic material, uas yog RNA, rau hauv tib neeg cov khoom siv caj ces, uas yog DNA.
Pom zoo:
Cov tshuaj twg yog nucleoside thim rov qab transcriptase inhibitors?
Available NRTIs zidovudine (Retrovir) Ylamivudine (Epivir) abacavir sulfate (Ziagen) didanosine (Videx) delayed-tso didanosine (Videx EC) stavudine (Zerit) emtricitabine (Emtriva) tenofovir disoproxil fumarate (Viread) Dab tsi yog nucleoside thim rov qab transcriptase enzyme inhibitors?
Puas thim rov qab transcriptase siv dna ua tus qauv?
Reverse transcriptase thawj zaug sau cov khoom sib txuas ntawm DNA los ua RNA: DNA hybrid. Tom ntej no, thim rov qab transcriptase los yog RNase H degrades RNA strand ntawm hybrid. Lub ib leeg-stranded DNA yog siv los ua tus qauv rau kev sib txuas ob-stranded DNA (cDNA).
Puas thim rov qab transcriptase puas muaj ntawv pov thawj?
Reverse transcriptase (RT) enzymes luam RNA rau hauv DNA. Tsis zoo li ntau DNA polymerases, RT enzymes tsis muaj cov ntawv pov thawj uas kuaj xyuasrau qhov tsis raug hauv DNA tshiab. Puas thim rov qab transcriptase muaj kev ua haujlwm kho?
Dab tsi yog qhov thim rov qab transcriptase inhibitors?
Reverse-transcriptase inhibitors yog ib chav kawm ntawm cov tshuaj tiv thaiv kab mob uas siv los kho tus kab mob HIV lossis AIDS, thiab qee kis kab mob siab B. RTIs inhibit kev ua haujlwm ntawm rov qab transcriptase, tus kab mob DNA polymerase uas xav tau rau kev rov ua dua ntawm HIV thiab lwm yam.
Puas yog thim rov qab transcriptase ib qho kev txwv enzyme?
Reverse transcriptase yog ib qho enzyme uas tsim los ntawm qee cov kab mob (retroviruses, uas khaws lawv cov ntaub ntawv caj ces li RNA tsis yog DNA), uas, raws li lub npe txhais, thim rov qab cov txheej txheem ntawm kev sau npe. Cov piv txwv ntawm kev txwv enzymes yog dab tsi?
