Reverse-transcriptase inhibitors yog ib chav kawm ntawm cov tshuaj tiv thaiv kab mob uas siv los kho tus kab mob HIV lossis AIDS, thiab qee kis kab mob siab B. RTIs inhibit kev ua haujlwm ntawm rov qab transcriptase, tus kab mob DNA polymerase uas xav tau rau kev rov ua dua ntawm HIV thiab lwm yam. retroviruses.
Yuav ua li cas thim rov qab transcriptase inhibitors ua haujlwm?
Nucleoside thim rov qab transcriptase inhibitors (NRTIs) thaiv kev thim rov qab transcriptase (tus kab mob HIV). HIV siv thim rov qab transcriptase los hloov nws RNA rau hauv DNA (reverse transcription). Blocking reverse transcriptase and reverse transcription tiv thaiv HIV los ntawm kev rov ua dua.
Dab tsi yog qhov thim rov qab transcriptase inhibitors piv txwv?
Thaum feem ntau teev nyob rau hauv kev txiav txim, NRTIs / NtRTIs yog nucleoside / nucleotide analogues ntawm cytidine, guanosine, thymidine thiab adenosine: Thymidine analogues: zidovudine (AZT) thiab stavudine (d4T) Cytidine analogues (ddC), lamivudine (3TC), thiab emtricitabine (FTC)
Cov tshuaj thim rov qab ua cov tshuaj transcriptase ua li cas?
Reverse transcriptase inhibitors yog nquag tawm tsam HIV, tus kab mob retrovirus. Cov tshuaj inhibit RNA virus replication los ntawm reversible inhibition ntawmtus kab mob HIV reverse transcriptase, uas thim rov qab transcribes tus kab mob RNA rau hauv DNA rau ntxig rau hauv tus tswv tsev DNA sib lawv liag (saib daim duab 51.6).
Cov tshuaj twg yog lub luag haujlwm rau inhibition of viral reverse transcriptase?
Management of HIV Infection
The NRTIs were thethawj chav kawm ntawm ARVs muaj rau kev kho mob HIV. NRTIs inhibit tus kab mob HIV rov qab transcriptase enzyme, uas yog lub luag haujlwm rau kev hloov pauv ntawm tus kab mob RNA rau hauv DNA.
