Cov tshuaj paclitaxel yog lipophilic hauv qhov xwm txheej thiab insoluble hauv dej. Nws daim ntawv tam sim no ua lag luam raws li kev txhaj tshuaj intravenous paclitaxel yog solubilized los ntawm kev siv Cremophor EL, uas yog cov nonionic surfactant thiab pab hauv micellar solubilization.
Dab tsi yog solubilizing agents?
Solubilization yog nce hauv solubility ntawm cov dej-soluble tsis zoo nrog cov neeg ua haujlwm saum npoo. Cov txheej txheem cuam tshuam nrog kev nkag mus (adsorbed lossis yaj) ntawm cov molecules hauv micelles thiab nyiam cov surfactants los tsim cov colloidal aggregations ntawm qhov tseem ceeb micelle concentration.
txhais li cas los ntawm micellar solubilization?
Micellar solubilization (solubilization) yog txheej txheem ntawm kev koom ua ke cov solubilizes (cov khoom uas ua rau solublization) rau hauv lossis mus rau micelles. Solublization yuav tshwm sim nyob rau hauv ib tug system uas muaj ib tug hnyav, ib tug koom haum colloid (ib tug colloid uas tsim micelles), thiab tsawg kawg yog ib tug lwm solubilization.
Lub luag haujlwm ntawm micellar solubilization yog dab tsi?
Lub Hom Phiaj: Micellar solubilization yog ib qho kev xaiv muaj zog rau kev ua kom cov tshuaj hydrophobic nyob rau hauv ib puag ncig aqueous. … Daim ntawv thov ntawm micelles hauv kev xa tshuaj, txhawm rau txo qis cov tshuaj degradation thiab poob, tiv thaiv kev mob tshwm sim, thiab ua kom cov tshuaj bioavailability, kuj tau nthuav tawm.
micelles tsim los ntawm dab tsi?
1.2. Micelles Structure. Micelles feem ntau yog tsim los ntawm amphiphilic molecules nyob rau hauv aqueous tovuas nws tus kheej sib sau ua ke rau hauv cov qauv uas muaj ob qho tib si hydrophobic thiab ib ntu hydrophilic (Tshooj 2) [13, 14, 15].
