Beta-globin yog ib feem (subunit) ntawm cov protein ntau hu ua hemoglobin, uas nyob hauv cov qe ntshav liab. Hauv cov neeg laus, hemoglobin ib txwm muaj plaub lub subunits protein: ob subunits ntawm beta-globin thiab ob subunits ntawm cov protein hu ua alpha-globin, uas yog tsim los ntawm lwm cov noob hu ua HBA.
Dab tsi yog txoj haujlwm ntawm amino acid hauv beta globin saw?
Lub hauv paus tshwj xeeb rau cov amino acids no yog: GTG/CAC/CTG/ACT/CCT/GAG. Sickle cell hemoglobin (Hemoglobin S) tshwm sim thaum, glutamic acid uas ib txwm muaj nyob rau hauv thib rau txoj haujlwmntawm beta globin saw yog hloov nrog valine.
Kev ua haujlwm ntawm beta globin yog dab tsi?
Cov beta globin protein yog ib qho ntawm cov subunits ntawm hemoglobin, ib qho protein tsim nyog rau cov pa oxygen nqa cov qe ntshav liab. Cov neeg uas muaj mob qog noj ntshav hauv ob daim ntawv theej ntawm HBB gene tsim cov proteins uas sib sau ua ke thiab ua rau muaj kev hloov pauv hauv cov duab thiab tus cwj pwm ntawm cov qe ntshav liab.
Muaj pes tsawg beta globin chains muaj?
Beta-thalassemia yog tshwm sim los ntawm kev txo qis (beta+) lossis tsis tuaj (beta0) kev sib txuas ntawm beta globin chains ntawm hemoglobin (Hb) tetramer, uas yog tsim los ntawm ob alpha globin thiab ob beta globin chains (alpha 2 beta 2).
beta globin yog dab tsi?
Tag nrho beta-globin protein yog 146 amino acids ntev. Nws muaj8 alpha helices - txuas los ntawm kev tig - tsim qhov hu ua "globin quav". Cov beta-globin protein khi ib pawg heme - ib qho me me molecule nrog ib tug hlau atom, uas khi oxygen.