Keeb kwm: Cyclosporine ua rau intrarenal vasoconstriction, uas yuav suav rau nws cov kev mob tshwm sim nephrotoxic. Plasma qib ntawm vasoconstrictor peptide endothelin-1 tau nce ntxiv tom qab kev tswj hwm cyclosporine, thiab endothelin-1 tau pom tias ua rau lub raum vasoconstriction.
Intrarenal vasoconstriction yog dab tsi?
Intrarenal vasoconstriction yog lub luag haujlwm tseem ceeb rau txo GFR hauv cov neeg mob ATN. Cov kws kho mob ntawm cov vasoconstriction no tsis paub, tab sis kev raug mob tubular zoo li yog qhov tseem ceeb hauv kev tshawb nrhiav.
Cov tshuaj dab tsi tuaj yeem ua rau ATN?
Cov nephrotoxins feem ntau suav nrog cov hauv qab no:
- Aminoglycosides.
- YAmphotericin B.
- Cisplatin thiab lwm yam tshuaj khomob.
- Radiocontrast (tshwj xeeb yog ionic siab osmolar agents muab IV hauv ntim > 100 mL-saib Contrast Nephropathy.
Cov tshuaj nephrotoxic yog dab tsi?
Cov tshuaj uas tuaj yeem ua rau lub raum puas yog lub npe hu ua "cov tshuaj nephrotoxic." Cov tshuaj no tuaj yeem ua rau lub raum puas. Qee cov tshuaj no ua rau lub raum ua haujlwm tsis zoo thiab lwm yam tuaj yeem ua rau mob raum mob.
Dab tsi ua rau lub raum vasoconstriction?
Kev txo qis ntawm kev ua siab ntev ua rau vasodilation thiab nce ntshav ntws los ntawm ob lub raum thaum so. Thaum qhov zaus ntawm qhov kev txiav txim muaj peev xwmnce, arteriolar du nqaij constricts (vasoconstriction), ua rau diminished glomerular flow, yog li tsawg pom tshwm sim.
