Levodopa yog a prodrug uas hloov mus rau dopamine los ntawm DOPA decarboxylase DOPA decarboxylase Mechanism of action
Levodopa yog hloov mus dopaminelos ntawm kev ua ntawm ib txwm muaj enzyme hu ua DOPA decarboxylase. Qhov no tshwm sim ob qho tib si nyob rau hauv lub peripheral ncig thiab nyob rau hauv lub hauv paus paj hlwb system tom qab levodopa tau hla cov ntshav hlwb barrier. https://en.wikipedia.org › wiki › Carbidopa › levodopa
Carbidopa/levodopa - Wikipedia
thiab tuaj yeem hla cov ntshav-hlwb barrier. Thaum nyob rau hauv lub hlwb, levodopa yog decarboxylated rau dopamine thiab nkoos lub dopaminergic receptors, yog li them nyiaj rau lub depleted mov ntawm endogenous dopamine pom nyob rau hauv Parkinson tus kab mob.
Vim li cas levodopa prodrug?
L-dopa yog suav tias yog prodrug , txhais tau tias nws tsis tau qhib kom txog thaum nws hla cov ntshav hlwb thaiv ntawm kev thauj mus los. Qhov tseem ceeb ntawm kev siv Levodopa yog txhawm rau kho cov qib dopamine depleted ntawm presynaptic davhlau ya nyob twg ntawm substantia nigra, uas rov ua haujlwm ua haujlwm.
YPuas levodopa puas yog metabolite?
Vim levodopa yog tswj hwm nrog peripheral acting DDI, nws yog feem ntau hloov mus rau nws metabolite 3-O-methyldopa (3-OMD) los ntawm ubiquitous enzyme catechol-O-methyltransferase (COMT) nyob rau hauv cov ntshav, peripheral cov ntaub so ntswg thiab nigrostriatal neurons.
YPuas levodopa puas yog metabolite ntawm dopamine?
Ib zaug levodopa tau nkag mus rau hauvcentral paj hlwb, nws yog metabolized rau dopamine los ntawm aromatic-l-amino-acid decarboxylase. LD hloov mus rau dopamine hauv lub cev ua ntej mus txog lub hlwb.
Cov zaub mov twg muaj L-DOPA siab?
taum dav (tseem hu ua Velvet Beans) yog hom taum tshwj xeeb uas tau pom tias muaj L-DOPA siab thiab txhawb kev tsim dopamine. Yogurt, kefir, sauerkraut, thiab lwm yam khoom noj fermented yog nplua nuj nyob rau hauv kev noj qab haus huv cov kab mob hu ua probiotics.
