Nws yog ib qho qauv molecule uas muaj feem cuam tshuam nrog anthracene nrog ib qho ntawm cov pawg CH hauv nruab nrab hloov los ntawm nitrogen. Zoo li cov molecules pyridine thiab quinoline, acridine yog me ntsis yooj yim. Nws yog ib qho yuav luag tsis muaj xim, uas crystallizes hauv koob.
Puas yog acridine muaj cov qauv bicyclic?
Acridine yog polycyclic heteroarene uas yog anthracene nyob rau hauv uas ib qho ntawm lub hauv paus CH pawg tau hloov los ntawm nitrogen atom. Nws muaj lub luag haujlwm ua genotoxin. Nws yog mancude organic heterotricyclic niam txiv, polycyclic heteroarene thiab cov tswv cuab ntawm acridines.
Dab tsi yog tshuaj acridine ring system?
Mepacrine (quinacrine), tshuaj acridine-based antimalarial tshuaj, tau tshawb pom xyoo 1932, thiab tau siv thaum Ntiaj Teb Tsov Rog II (1939-45) vim tsis muaj chloroquine. Xyoo 1944, penicillin tau hloov kho acridine raws li tshuaj tua kab mob [1].
Puas yog acridine ib txiv kab ntxwv?
Acridine Txiv kab ntxwv yog cell-permeant nucleic acid khi dyeuas tawm cov fluorescence ntsuab thaum khi rau dsDNA thiab liab fluorescence thaum khi rau ssDNA lossis RNA. Cov yam ntxwv tshwj xeeb no ua rau acridine txiv kab ntxwv muaj txiaj ntsig rau kev tshawb fawb ntawm tes. Acridine txiv kab ntxwv kuj tau siv los ua lysosomal dye.
Hom mutagen twg yog acridine txiv kab ntxwv?
Acridine txiv kab ntxwv yog cell-permeable, uas tso cai rau cov xim tuaj yeem cuam tshuam nrog DNA los ntawm kev sib cuam tshuam, lossis RNA ntawm electrostatic attractions. Thaum khirau DNA, acridine txiv kab ntxwv zoo ib yam li spectrally rau cov organic compound hu ua fluorescein.
