2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Tus qauv tsim kom haum yog thawj zaug los ntawm Koshland hauv xyoo 1958 los piav qhia txog kev hloov pauv ntawm cov protein hauv cov txheej txheem khi. Cov qauv no qhia tau hais tias ib qho enzyme, thaum khi nrog nws cov substrate, optimizes lub interface los ntawm lub cev kev sib cuam tshuam los tsim ib tug complex qauv.
Yuav ua li cas ua kom haum txoj kev xav?
allosteric tswj
…lub hauv paus ntawm qhov kev xav ntawm qhov kev xav ua kom haum, uas tau hais tias kev khi ntawm lub substrate lossis lwm yam molecule rau ib qho enzyme ua rau muaj kev hloov pauv hauv lub cev. Cov duab ntawm cov enzyme thiaj li txhim kho lossis inhibit nws txoj haujlwm.
Leej twg npaj xauv thiab qhov tseem ceeb hypothesis thiab induced haum hypothesis?
Xauv thiab qhov kev xav tseem ceeb tau npaj los ntawm Emil Fisher 1884. Induced fit hypothesis tau hais los ntawm Daniel E. Koshland 1973.
Leej twg tsim lub ntsuas phoo thiab qhov tseem ceeb?
…thiab enzyme, hu ua "tus yuam sij-xauv" kev xav, tau tawm tswv yim los ntawm German chemist Emil Fischer hauv xyoo 1899 thiab piav qhia txog ib qho tseem ceeb ntawm cov enzymes, lawv qhov tshwj xeeb.. Nyob rau hauv feem ntau ntawm cov enzymes kawm txog tam sim no, ib tug cleft, los yog indentation, nyob rau hauv uas lub substrate haum yog pom nyob rau hauv lub active…
Txoj kev xav ua kom haum ua haujlwm li cas?
Tus qauv tsim nyog hais tias ib lub substrate khi rau qhov chaw nquag thiab ob qho tib si hloov pauv me ntsis, tsim kom muaj qhov zoo tagnrho rau catalysis. Thaum ib qho enzyme khi nws cov substrate nws tsim ib qho enzyme-substratecomplex. … Lub enzyme yuav nco ntsoov rov qab mus rau nws qhov qub qub thaum ua tiav cov tshuaj tiv thaiv.
Pom zoo:
Txoj kev txawj ntse twg tau txais kev xav thiab kev xav?
Romanticism: 18th caug xyoo kev ua yeeb yam thiab kev txawj ntse uas txhawb kev xav, kev ywj pheej, thiab kev xav ntawm tus kheej. Fab Kis xyoo kaum yim lub tsev kho kom zoo li cas ua rau tus ntsuj plig ntawm rococo style? Fab Kis xyoo kaum yim-xyoo pua salons ua dab tsi ua rau tus ntsuj plig ntawm Rococo style?
Leej twg tau npaj txoj kev xav triarchic ntawm kev txawj ntse?
Nrog rau qhov no hauv siab, Sternbergtau npaj nws txoj kev xav triarchic ntawm tib neeg kev txawj ntse ua ib qho kev cuam tshuam nrog peb yam ntawm kev txawj ntse. Leej twg tsim txoj kev xav Triarchic ntawm kev txawj ntse? Robert Sternberg tau tsim lwm txoj kev xav ntawm kev txawj ntse, uas nws hu ua txoj kev xav triarchic ntawm kev txawj ntse vim nws pom kev txawj ntse muaj peb ntu (Sternberg, 1988):
Qhov twg copernicus nrhiav tau txoj kev xav heliocentric?
Thaum Galileo tsis qhia Bruno txoj hmoo, nws raug sim rau kev ua txhaum cai raws li Roman Inquisition thiab muab tso rau hauv tsev raug kaw rau lub neej. Galileo nrhiav tau pov thawj los txhawb Copernicus 'heliocentric txoj kev xav thaum nws saib plaub lub hli nyob rau hauv orbit ncig Jupiter.
Leej twg muab qhov kev xav ntawm convection tam sim no txoj kev xav?
Txoj kev xav no tau tawm tswv yim los ntawm German meteorologist thiab geologist Alfred Wegener Alfred Wegener Thaum lub sijhawm nws lub neej nws tau paub zoo txog nws qhov kev ua tiav hauv huab cua thiab ua tus pioneer ntawm kev tshawb fawb polar, tab sis hnub no nws tau nco ntsoov ntau tshaj plaws.
Leej twg xav txog qhov tseem ceeb ntawm kev nrhiav txoj hauv kev nruab nrab?
Nagarjuna , (kev vam meej 2nd century ce), Indian Buddhist philosopher uas qhia txog cov lus qhuab qhia ntawm qhov tsis muaj dab tsi (shunyata shunyata Sunyata, hauv kev ntseeg hauv kev ntseeg, qhov tsis muaj tseeb uas ua qhov tseeb qhov kawg;
