Tus qauv tsim kom haum yog thawj zaug los ntawm Koshland hauv xyoo 1958 los piav qhia txog kev hloov pauv ntawm cov protein hauv cov txheej txheem khi. Cov qauv no qhia tau hais tias ib qho enzyme, thaum khi nrog nws cov substrate, optimizes lub interface los ntawm lub cev kev sib cuam tshuam los tsim ib tug complex qauv.
Yuav ua li cas ua kom haum txoj kev xav?
allosteric tswj
…lub hauv paus ntawm qhov kev xav ntawm qhov kev xav ua kom haum, uas tau hais tias kev khi ntawm lub substrate lossis lwm yam molecule rau ib qho enzyme ua rau muaj kev hloov pauv hauv lub cev. Cov duab ntawm cov enzyme thiaj li txhim kho lossis inhibit nws txoj haujlwm.
Leej twg npaj xauv thiab qhov tseem ceeb hypothesis thiab induced haum hypothesis?
Xauv thiab qhov kev xav tseem ceeb tau npaj los ntawm Emil Fisher 1884. Induced fit hypothesis tau hais los ntawm Daniel E. Koshland 1973.
Leej twg tsim lub ntsuas phoo thiab qhov tseem ceeb?
…thiab enzyme, hu ua "tus yuam sij-xauv" kev xav, tau tawm tswv yim los ntawm German chemist Emil Fischer hauv xyoo 1899 thiab piav qhia txog ib qho tseem ceeb ntawm cov enzymes, lawv qhov tshwj xeeb.. Nyob rau hauv feem ntau ntawm cov enzymes kawm txog tam sim no, ib tug cleft, los yog indentation, nyob rau hauv uas lub substrate haum yog pom nyob rau hauv lub active…
Txoj kev xav ua kom haum ua haujlwm li cas?
Tus qauv tsim nyog hais tias ib lub substrate khi rau qhov chaw nquag thiab ob qho tib si hloov pauv me ntsis, tsim kom muaj qhov zoo tagnrho rau catalysis. Thaum ib qho enzyme khi nws cov substrate nws tsim ib qho enzyme-substratecomplex. … Lub enzyme yuav nco ntsoov rov qab mus rau nws qhov qub qub thaum ua tiav cov tshuaj tiv thaiv.
