Hexokinase tau dhau los ua qhov kev hloov pauv hloov pauv thaum qabzib khi. Qhov kev hloov pauv no tiv thaiv hydrolysis ntawm ATP, thiab yog allosterically inhibited los ntawm physiological concentrations ntawm qabzib-6-phosphate cov khoom.
Hexokinase ua haujlwm li cas?
Kinetics thiab Inhibition ntawm Hexokinase
Hexokinase ua kom glycoloysis los ntawm phosphorylating qabzib. … Cov ntaub so ntswg uas muaj hexokinase siv cov piam thaj hauv cov ntshav qis. G6P inhibits hexokinase los ntawm kev khi rau N-terminal domain (qhov no yog kev tawm tswv yim yooj yim inhibition). Nws sib tw inhibits kev khi ntawm ATP [8].
Dab tsi ua rau hexokinase hauv glycolysis?
Hexokinase, enzyme catalyzing thawj kauj ruam ntawm glycolysis, yog inhibited los ntawm nws cov khoom, glucose 6-phosphate. … Nyob rau hauv lem, qib ntawm qabzib 6-phosphate nce vim nws nyob rau hauv equilibrium nrog fructose 6-phosphate. Yog li, qhov inhibition ntawm phosphofructokinase ua rau inhibition ntawm hexokinase.
Kev ua ntawm hexokinase yog dab tsi?
Hexokinase (HK), lub cell liab enzyme nrog cov haujlwm qis tshaj plaws hauv txoj hauv kev glycolytic, catalyzes thawj kauj ruam hauv kev siv cov piam thaj thiab yog li yuav tsum tau rau ob qho tib si glycolysis thiab Lub pentose shunt thiab tsim cov piam thaj 6-phosphate.
Puas insulin qhib hexokinase?
Insulin muaj ntau yam teebmeem hauv daim siab uas txhawb nqa glycogen synthesis. Ua ntej, nws qhib lub enzymehexokinase, uas phosphorylates qabzib, ntxiab nws hauv cell.
