Taw qhia. Kuj tseem hu ua statins, HMG-CoA reductase inhibitors ua haujlwm los ntawm inhibiting lub synthesis ntawm cov roj cholesterol hauv daim siab los ntawm enzyme HMG-CoA reductase.
HMG-CoA reductase nyob qhov twg?
Nyob rau hauv tib neeg, cov noob rau HMG-CoA reductase (NADPH) nyob ntawm caj npab ntev ntawm tsib chromosome (5q13. 3-14). Cov enzymes uas muaj qhov ua haujlwm zoo ib yam kuj tseem muaj nyob hauv lwm yam tsiaj, nroj tsuag thiab kab mob.
HMG-CoA reductase inhibitor ua haujlwm li cas?
β-Hydroxy β-methylglutaryl-CoA (HMG-CoA) reductase inhibitors, nrov npe hu ua statins, ua haujlwm los ntawm kev txo cov roj cholesterol hauv lub cev. HMG-CoA inhibitors cuam tshuam nrog lub peev xwm ntawm lub cev los tsim cov roj cholesterol los ntawm kev noj cov rog. … Statins khi rau qhov chaw nquag ntawm cov enzyme thiab hloov nws cov qauv.
HMG-CoA reductase ua dab tsi?
Cov roj (cholesterol) Precursors. HMG-CoA reductase yog tus tus nqi txwv enzyme ntawm cov roj cholesterol biosynthesis. Kev qhia theem ntawm cov enzyme membrane-bound yog tswj los ntawm ntau yam uas nyob rau hauv lem tswj cov cholesterol synthesis thiab cellular cholesterol homeostasis (saib hauv [1]).
Lub cev twg yog qhov chaw ua haujlwm rau HMG-CoA reductase inhibitors?
Cov teebmeem no tshwm sim loj heev hauv lub siab, qhov twg cov statins feem ntau faib [2]. Cov txiaj ntsig tseem ceeb ntawm cov tshuaj no yog qhov txo qis hauv LDL-cholesterol hauv cov ntshav.
