Thaum lub sijhawm puberty, cov tib neeg uas muaj 5-alpha reductase deficiency feem ntau tsim qee cov txiv neej sib deev yam ntxwv xws li nce cov leeg nqaij, lub suab sib sib zog nqus, thiab kev loj hlob ntawm cov txiv neej sab nraud genitalia, tab sis feem ntau ntawm cov txiv neej no yug tsis tau me nyuam.
5-alpha-reductase ua dab tsi?
Lub enzyme 5-alpha reductase muaj nyob rau hauv me me hauv cov leeg thiab hloov testosterone rau dihydrotestosterone (DHT). Testosterone cuam tshuam rau cov nqaij ntshiv ntawm lub cev, cov leeg nqaij, cov leeg lub zog, thiab kev ua haujlwm ntawm kev sib deev hauv cov txiv neej.
Puas muaj kev kho mob rau 5-alpha-reductase deficiency?
Kev kho tshuaj ntau dua (250-500 mg 1-2 zaug hauv ib lub lis piam muab rau 6-36 mo) tau siv rau cov neeg mob pubertal lossis postpubertal. Hauv cov neeg mob uas muaj 5-alpha-reductase tsis txaus uas yog poj niam loj hlob, tshuaj hloov tshuaj estrogen yuav tsum tau pib thaum muaj pob txha muaj hnub nyoog 12 xyoos lossis ib zaug pom qhov nce hauv gonadotropins.
Dab tsi nce 5-alpha-reductase?
Ob tus neeg mob rog thiab tsis rog PCOS muaj 5 qhov kev ua haujlwm alpha-reductase ntau dua li kev tswj hwm (tag nrho P < 0.05). … Cov lus xaus: PCOS yog txuam nrog txhim kho androgen thiab cortisol metabolite excretionthiab nce 5 alpha-reductase kev ua haujlwm uas tsis tuaj yeem piav qhia los ntawm kev rog ib leeg.
YYuav ua li cas hom enzyme yog 5-alpha-reductase?
5α-Reductases, tseem hu ua 3-oxo-5α-steroid 4-dehydrogenases, yog enzymes koom nrogsteroid metabolism. Lawv koom nrog peb txoj hauv kev metabolic: bile acid biosynthesis, androgen thiab estrogen metabolism. Muaj peb isozymes ntawm 5α-reductase encoded los ntawm cov noob SRD5A1, SRD5A2, thiab SRD5A3.
