Phosphatase thiab tensin homolog yog phosphatase, hauv tib neeg, yog encoded los ntawm PTEN noob. Kev hloov pauv ntawm cov noob no yog ib kauj ruam hauv kev loj hlob ntawm ntau cov qog nqaij hlav, tshwj xeeb tshaj yog glioblastoma, mob ntsws cancer, mob qog noj ntshav mis, thiab mob qog nqaij hlav prostate.
Lub luag haujlwm ntawm PTEN phosphate thiab TENsin homolog ntawm chromosome 10 yog dab tsi?
PTEN (phosphatase thiab tensin homolog tshem tawm ntawm chromosome 10) yog cov qog qog nqaij hlav, hloov ntau zaus hauv ntau hom qog nqaij hlav hauv tib neeg. PTEN tswj kev loj hlob ntawm tes, apoptosis, thiab kev loj hlob. Phosphorylation hauv PTEN tus Tsov tus tw ua rau nws inactivation thiab txo nws degradation.
PTEN phosphatase ua dab tsi?
PTEN ua raws li cov qog nqaij hlav qog los ntawm kev ua ntawm nws cov khoom noj phosphatase protein. Cov phosphatase no koom nrog kev tswj hwm ntawm lub voj voog ntawm tes, tiv thaiv cov hlwb los ntawm kev loj hlob thiab kev faib tawm sai heev. Nws yog lub hom phiaj ntawm ntau cov tshuaj tiv thaiv kab mob.
YPuas yog PTEN yog tyrosine phosphatase?
Kev ua haujlwm lom neeg ntawm PTEN qog nqaij hlav yog feem ntau yog vim nws txoj haujlwm lipid phosphatase. Txoj kev tshawb no qhia tau hais tias cov tsiaj nyeg PTEN yog protein tyrosine phosphataseuas xaiv dephosphorylates insulin receptor substrate-1 (IRS1), tus neeg nruab nrab ntawm insulin thiab IGF signals.
PTEN qhov zoo txhais li cas?
Koj qhov kev kuaj pom tias koj muaj pathogenic mutation (ib kab mob ua rau hloov pauv hauv cov noob, zoo li kev sau ntawv yuam kev) lossisvariant uas zoo li pathogenic hauv PTEN noob. Ob qho ntawm cov txiaj ntsig no yuav tsum suav tias yog qhov zoo.
