De novo lipogenesis yog txheej txheem uas carbon precursors ntawm acetyl-CoA yog synthesized rau fatty acids. Lipogenesis feem ntau yog muab los ntawm cov carbohydrates thiab yog ib qho me me rau cov khw muag khoom lipid tag nrho lub cev, ua rau 1-3% ntawm tag nrho cov rog hauv tib neeg noj cov zaub mov raug.
Qhov twg yog lipogenesis synthesized?
Fatty acid synthesis tshwm sim hauv cytoplasm ntawm cov hlwb thaum oxidative degradation tshwm sim hauv mitochondria. Muaj ntau cov enzymes rau fatty acid synthesis yog tsim rau hauv ib tug multienzyme complex hu ua fatty acid synthase. Qhov chaw loj ntawm fatty acid synthesis yog cov ntaub so ntswg adipose thiab lub siab.
Dab tsi yog fatty acids Synthesized los ntawm?
Fatty acids feem ntau yog tsim los ntawm acetyl-CoA, txheej txheem uas yuav tsum muaj ATP, biotin, Mg ++, thiab Mn ++. Acetyl-CoA carboxylase, tus nqi-txheej enzyme hauv fatty acid biosynthesis, yog inhibited los ntawm glucagon thiab epinephrine, thiab stimulated los ntawm insulin.
Qhov kev sib txuas ntawm fatty acids tshwm sim nyob qhov twg?
Fatty acids yog synthesized nyob rau hauv the cytosol, whereas acetyl CoA yog tsim los ntawm pyruvate nyob rau hauv mitochondria. Yog li ntawd, acetyl CoA yuav tsum raug xa los ntawm mitochondria mus rau cytosol.
YPuas yog lipogenesis thiab fatty acid synthesis tib yam?
Fat accumululation yog txiav txim los ntawm qhov sib npaug ntawm cov roj synthesis (lipogenesis) thiab rog tawg (lipolysis / fatty acid oxidation). Lipogenesis encompasses cov txheej txheem ntawm fatty acid synthesis thiab tom qab triglyceride synthesis, thiab tshwm sim nyob rau hauv ob lub siab thiab adipose ntaub so ntswg (Daim duab 1).
