Kev tsim ntawm Bilirubin Kwv yees, 80% ntawm bilirubin yog tsim los ntawm kev tawg ntawm hemoglobin hauv senescent cov qe ntshav liab, thiab ua kom puas erythroid hlwb hauv pob txha pob txha. Cov seem yog tshwm sim los ntawm kev hloov pauv ntawm ntau yam heme-muaj protein ntau pom nyob rau hauv lwm cov ntaub so ntswg, feem ntau ntawm daim siab thiab cov leeg.
bilirubin tsim los ntawm dab tsi?
Bilirubin yog xim daj daj muaj nyob hauv cov kua tsib. Nws yog tsim thaum lub siab tawg cov qe ntshav liab qub. Bilirubin raug tshem tawm ntawm lub cev los ntawm cov quav (quav) thiab muab cov quav tso rau nws cov xim ib txwm muaj.
Qhov twg hemoglobin tawg mus rau hauv bilirubin?
Bilirubin, cov xim daj daj daj ntawm cov kua tsib, zais los ntawm lub siab hauv vertebrates, uas muab rau cov khoom pov tseg (quav) lawv cov xim xim. Nws yog tsim nyob rau hauv cov pob txha hlwb thiab nyob rau hauv daim siab raws li qhov kawg khoom ntawm cov ntshav liab-cell (hemoglobin) puas.
Dab tsi hloov heme rau bilirubin?
Senescent erythrocytes yog phagocytosed thiab degraded loj los ntawm macrophages tam sim no nyob rau hauv tus po thiab daim siab. Hauv cov hlwb no, Heme yog thawj zaug hloov mus rau bilirubin hauv ob-kauj ruam enzymatic txheej txheem uas ua haujlwm " Biliverdin" ua ib qho nruab nrab. … Cov macrophages tom qab ntawd tso tawm cov txiaj ntsig bilirubin rau hauv plasma.
Yuav ua li cas conjugated bilirubin yogtsim?
Nyob rau hauv cov hlab ntsha, unconjugated bilirubin khi rau albumin los pab nws thauj mus rau daim siab. Ib zaug hauv daim siab, glucuronic acid ntxiv rau unconjugated bilirubin los ntawm enzyme glucuronyl transferase. Qhov no tsim conjugated bilirubin, uas yog soluble.
Bilirubin Metabolism Simplified
