Insulin tswj ncaj qha ntawm gluconeogenesis los ntawm kev ua ntawm daim siab, tab sis kuj cuam tshuam tsis ncaj qha rau gluconeogenesis los ntawm kev ua rau lwm cov ntaub so ntswg. Qhov cuam tshuam ncaj qha ntawm insulin tau pom nyob rau hauv cov dev yoo mov, qhov twg portal plasma insulin inhibited hepatic qabzib ntau lawm.
Y Puas insulin inhibit gluconeogenesis?
Insulin tseem tuaj yeem txhawb nqa glycogen synthesis, inhibit glycogen breakdown, thiab suppress gluconeogenesis (7–11).
YPuas insulin nce glycogenolysis?
insulin tsis txaus ua rau muaj kev nce hauv glycogenolysis thiab yog li nce hauv glycolytic intermediates hauv siab, suav nrog F2, 6P 2, uas ua rau kom nce glycolysis thiab hepatic lactate tso zis nrog rau inhibition ntawm gluconeogenic flux rau G6P (7, 8).
Puas yog qib siab ntawm insulin nce gluconeogenesis?
Ntxiv mus, insulin inhibits qhov tso tawm ntawm glucagon, paub txog kev ua haujlwm ntawm gluconeogenesis (5), yog li ua rau muaj kev cuam tshuam tsis ncaj rau cov txheej txheem hauv daim siab. Tsis tas li ntawd, insulin inhibits lipolysis (6), uas txo qis glycerol thiab nonesterified dawb fatty acid (NEFA) qib.
Dab tsi txhawb nqa gluconeogenesis?
Gluconeogenesis yog txhawb los ntawm cov tshuaj hormones ntshav qab zib (glucagon, kev loj hlob hormone, epinephrine, thiab cortisol). Gluconeogenic substrates suav nrog glycerol, lactate, propionate, thiab qee cov amino acids. … Ntawm cov amino acidsthauj mus rau daim siab los ntawm cov leeg thaum lub sij hawm qoj ib ce thiab tshaib plab, Ala predominates.
