Lub xub ntiag ntawm granulocyte colony stimulating factor (G-CSF), TNF thiab Hom I thiab II interferons (IFNs) tuaj yeem nrhiav thiab / lossis qhib neutrophils [6]. Thaum stimulation ntawm neutrophils, muaj ib tug secretion ntawm CXC-chemokines, uas yog lub luag hauj lwm rau chemotaxis ntawm ze-los ntawm neutrophils rau lub site.
Yuav ua li cas thiaj nrhiav tau neutrophils?
Neutrophil recruitment yog pib los ntawm hloov pauv ntawm qhov chaw endotheliumuas tshwm sim los ntawm kev txhawb nqa los ntawm cov neeg kho mob inflammatory (xws li histamine, cysteyl- leukotrienes thiab cytokines) uas tawm ntawm cov ntaub so ntswg - neeg nyob. sentinel leukocytes thaum lawv nkag mus rau cov kab mob 1, 2, 4.
Yuav ua li cas chemokines nyiam neutrophils?
The ELR+ chemokines nyiam feem ntau neutrophils thiab yog angiogenic, thaum ELR- chemokines yog angiostatic thiab nyiam feem ntau lymphocytes. Ob tsev neeg chemokine tseem me me, thiab suav nrog XC tsev neeg (Fig.
Cytokines dab tsi txhawb kev tsim neutrophil?
Neutrophils yog lub hom phiaj zoo ntawm cov cytokines proinflammatory, piv txwv li, IL-1 thiab TNF- a, ntawm chemokines xws li IL-8, thiab kev loj hlob yam xws li granulocyte / monocyte colony stimulating yam (G-CSF thiab GM-CSF).
Qhov twg ntawm cytokines nyiam neutrophils thiab inhibit cov kab mob?
Tsis tas li ntawd, so neutrophils tuaj yeem tsim los ntawm cov khoom siv kab mob: cytokines thiab chemokines suav nrog IL-8,IFN-γ, TNF-α, granulocyte macrophage colony-stimulating factor (GM-CSF), thiab platelet activating factor (PAF).
