tRNA, nrhiav tau los ntawm Paul Zamecnik thiab cov neeg koom tes [2], yog ib qho "adaptor" molecule [3] uas kho cov kev txhais cov ntaub ntawv los ntawm tus xa xov RNAs (mRNAs). tRNA yog thawj qhov tsis-coding RNA tau pom.
Thaum twg tRNA nrhiav tau?
Nws tau ua haujlwm hauv bacteriology thiab immunology department ntawm Harvard Medical School los ntawm 1952 txog 1967. Ua hauj lwm ua ke nrog Paul Zamecnik thiab Elizabeth Keller nws nrhiav tau thawj kauj ruam ntawm protein synthesis. Ob xyoos tom qab ntawd hauv 1958 Hoagland thiab Zemecnik pom tRNA.
Tus qauv ntawm tRNA hu ua dab tsi?
Lub tRNA molecule muaj qhov sib txawv folded qauv nrog peb plaub hau loops uas tsim cov duab ntawm peb nplooj clover. Ib qho ntawm cov kab plaub hau no muaj cov kab ke hu ua anticodon, uas tuaj yeem paub thiab txiav txim siab ib qho mRNA codon. Txhua tRNA muaj nws cov amino acid uas txuas mus rau nws qhov kawg.
tRNA nyob qhov twg?
tRNA lossis Hloov RNA
Zoo li rRNA, tRNA nyob nyob rau hauv lub cellular cytoplasmthiab koom nrog hauv cov protein synthesis. Hloov RNA coj lossis hloov cov amino acids mus rau ribosome uas sib haum rau txhua peb-nucleotide codon ntawm rRNA.
Lub hauv paus chiv keeb ntawm tRNA yog dab tsi?
Ib tus qauv rau tRNA molecule keeb kwm yog tham. Tus qauv postulates tias cov molecule no originated tsuas yog los ntawm kev duplication ncaj qha (thiab tom qab evolution) ntawm cov noob coding rau RNA hairpin qauv, uas tuaj yeemyog li no yuav tsum hypothesized raws li evolutionary precursor ntawm tRNA molecule.
