Kev hloov pauv lub xeev cov analogs yog tshuaj lom neeg ruaj khovtsim los ntes lub zog hloov pauv lub xeev ruaj khov los ntawm kev ua raws li cov duab geometric thiab electrostatic ntawm lub xeev hloov pauv.
Puas hloov pauv xeev cov tshuaj analogs enzymes?
Enzymes cuam tshuam nrog a substrate los ntawm kev lim lossis distortions, txav lub substrate mus rau lub xeev hloov. … Transition state analogs tuaj yeem siv los ua inhibitors hauv enzyme-catalyzed cov tshuaj tiv thaiv los ntawm thaiv qhov chaw nquag ntawm cov enzyme.
Puas hloov pauv lub xeev analogs ruaj khov?
Cov qauv hloov pauv hauv lub xeev muaj lub neej nyob rau ntawm fsec lub sijhawm thiab muaj qhov sib npaug ntawm kev faib rau reactant lossis khoom., Hloov pauv lub xeev analogue- cov tshuaj lom neeg ruaj khov nrog cov yam ntxwv ntawm daim ntawv cog lus qhov ntev, lub kaum ntse ntse thiab electron ceev ntawm van der Waals nto kom zoo li lub xeev hloov pauv tiag tiag…
Puas yog lub xeev kev hloov pauv ib qho chaw ruaj khov?
Lub xeev hloov pauv yog lub xeev sib raug rau lub zog siab tshaj plaws raws li kev sib koom ua ke. Nws muaj ntau lub zog dawb hauv kev sib piv rau cov substrate lossis cov khoom; yog li no, nws yog lub xeev ruaj khov tshaj plaws.
Puas hloov lub xeev analog thim rov qab?
Fluorinated Compound nyob rau hauv Enzyme-Catalyzed Reactions
Peptidyl trifluoromethyl ketones yog cov piv txwv ntawm kev thim rov qab, hloov lub xeev analog inhibitors ntawm serine proteases.
