Lub kev tshwm sim ntawm bromine nrog sodium hydroxidecov ntaub ntawv sodium hypobromite nyob rau hauv qhov chaw, uas hloov cov thawj amide mus rau hauv nruab nrab isocyanate. … Qhov nruab nrab isocyanate yog hydrolyzed mus rau thawj amine, muab cov pa roj carbon dioxide. Base abstracts ib acidic N-H proton, yielding anion.
Hoffman cov tshuaj tiv thaiv bromide yog dab tsi muab piv txwv?
Thaum ib qho amide raug kho nrog bromine hauv cov dej los yog ethanolic tov ntawm sodium hydroxide, degradation ntawm amide tshwm sim ua rau tsim cov thawj amine. Cov tshuaj tiv thaiv no suav nrog kev degradation ntawm amide thiab yog nrov npe hu ua Hoffmann bromamide degradation cov tshuaj tiv thaiv.
Tus neeg nruab nrab twg koom nrog Hoffman cov tshuaj tiv thaiv?
Nyob rau hauv Hofmann rearrangement, ib qho amide raug rau cov txheej txheem oxidation nrog hypobromite los ua an N-bromoamide intermediate, uas nyob rau hauv lub xub ntiag ntawm ib tug undergoes ib tug deprotonation kauj ruam ua raws. los ntawm kev tsiv teb tsaws ntawm ib pawg alkyl mus rau nitrogen atom, thiab ib txhij poob ntawm bromine, uas yog ib qho isocyanate yog …
Hoffmann Bromamide cov tshuaj tiv thaiv sau nrog kab zauv yog dab tsi?
Peb tuaj yeem sau cov kab zauv dav dav rau cov tshuaj tiv thaiv no raws li hauv qab no. $RCON{H_2} + B{r_2} + 4NaOH \to RN{H_2} + N{a_2}C{O_3} + 2NaBr + 2{H_2}O$ qhov twg R coj raws li ib tug dav aliphatic los yog aromatic organic compound.
Cov tshuaj twg ua ethylamine hauv Hoffman cov tshuaj tiv thaiv?
HoffmanCov tshuaj tiv thaiv bromamide muaj feem xyuam rau ob qho tib si aliphatic thiab aromatic compounds. Potassium hypobromite kuj tseem siv tau los ua cov tshuaj reagent hauv cov tshuaj tiv thaiv no.
