Nws tau xaus lus tias insulin xav tias tsis ua haujlwmPFK 2 los ntawm kev hloov pauv hauv cAMP thiab qib effector lossis los ntawm inhibition ntawm cAMP-dependent protein kinase dissociation. Cov ntaub ntawv txhawb nqa qhov kev xav tias insulin tuaj yeem ua los ntawm kev ua kom PFK 2 phosphatase.
YPuas yog phosphofructokinase stimulated los ntawm insulin?
Insulin txhawb kev khi ntawm phosphofructokinaserau cytoskeleton thiab nce qabzib 1, 6-bisphosphate qib hauv NIH-3T3 fibroblasts, uas tiv thaiv los ntawm cov tshuaj tiv thaiv calmodulin.
phosphofructokinase yog dab tsi?
PFK1 yog allosterically qhib los ntawm siab concentration ntawm AMP, tab sis qhov muaj zog tshaj plaws activator yog fructose 2, 6-bisphosphate, uas kuj yog tsim los ntawm fructose-6-phosphate los ntawm PFK 2. Yog li, qhov ntau ntawm F6P ua rau muaj ntau dua ntawm fructose 2, 6-bisphosphate (F-2, 6-BP).
insulin thiab glucagon tswj Phosphofructokinase 1 li cas?
Insulin tso cai rau cov piam thaj coj mus thiab siv los ntawm cov ntaub so ntswg. Yog li, glucagon thiab insulin yog ib feem ntawm cov lus tawm tswv yim uas ua kom cov ntshav qabzib nyob ruaj khov. Cov kev cai meej ntawm PFK1 tiv thaiv glycolysis thiab gluconeogenesis los ntawm qhov tshwm sim ib txhij.
Dab tsi inhibits thiab ua kom phosphofructokinase?
Citrate inhibits phosphofructokinase los ntawm kev txhim kho cov nyhuv inhibitory ntawm ATP. … Fructose 2,6-bisphosphate activates phosphofructokinase los ntawm kev nce nws cov affinity rau fructose 6-phosphate thiab txo qis cov nyhuv inhibitory ntawm ATP (Daim duab 16.18).
