2024 Tus sau: Elizabeth Oswald | [email protected]. Kawg hloov kho: 2024-01-13 00:07
Nws tau xaus lus tias insulin xav tias tsis ua haujlwmPFK 2 los ntawm kev hloov pauv hauv cAMP thiab qib effector lossis los ntawm inhibition ntawm cAMP-dependent protein kinase dissociation. Cov ntaub ntawv txhawb nqa qhov kev xav tias insulin tuaj yeem ua los ntawm kev ua kom PFK 2 phosphatase.
YPuas yog phosphofructokinase stimulated los ntawm insulin?
Insulin txhawb kev khi ntawm phosphofructokinaserau cytoskeleton thiab nce qabzib 1, 6-bisphosphate qib hauv NIH-3T3 fibroblasts, uas tiv thaiv los ntawm cov tshuaj tiv thaiv calmodulin.
phosphofructokinase yog dab tsi?
PFK1 yog allosterically qhib los ntawm siab concentration ntawm AMP, tab sis qhov muaj zog tshaj plaws activator yog fructose 2, 6-bisphosphate, uas kuj yog tsim los ntawm fructose-6-phosphate los ntawm PFK 2. Yog li, qhov ntau ntawm F6P ua rau muaj ntau dua ntawm fructose 2, 6-bisphosphate (F-2, 6-BP).
insulin thiab glucagon tswj Phosphofructokinase 1 li cas?
Insulin tso cai rau cov piam thaj coj mus thiab siv los ntawm cov ntaub so ntswg. Yog li, glucagon thiab insulin yog ib feem ntawm cov lus tawm tswv yim uas ua kom cov ntshav qabzib nyob ruaj khov. Cov kev cai meej ntawm PFK1 tiv thaiv glycolysis thiab gluconeogenesis los ntawm qhov tshwm sim ib txhij.
Dab tsi inhibits thiab ua kom phosphofructokinase?
Citrate inhibits phosphofructokinase los ntawm kev txhim kho cov nyhuv inhibitory ntawm ATP. … Fructose 2,6-bisphosphate activates phosphofructokinase los ntawm kev nce nws cov affinity rau fructose 6-phosphate thiab txo qis cov nyhuv inhibitory ntawm ATP (Daim duab 16.18).
Pom zoo:
Puas yog cov tshuaj insulin tsis tu ncua?
Yog cov tshuaj insulin tsis tu ncua ua huab, muab pov tseg, ADA hais. Nws tau poob nws cov txiaj ntsig, thiab yuav tsis ua kom koj cov ntshav qab zib kom siab dhau. Yog tias koj cov tshuaj insulin yog qhov sib xyaw ntawm NPH lossis ultralente insulins, koj tuaj yeem tau txais NPH lossis ultralente hauv lub raj mis ntawm cov tshuaj insulin.
Kuv puas tuaj yeem ua kom cov txiv laum huab xeeb ua kom du?
Rau cov txiv laum huab xeeb, do hauv qhov tshwj tseg txiv laum huab xeeb. Ntxiv cov txiv ntoo rau lub tais ntawm cov khoom noj processor. Txheej txheem 1 feeb ces txhuam sab ntawm lub tais nrog roj hmab spatula. Ua lwm 2 mus rau 3 feeb kom ci thiab du.
Puas yog insulin yog enzyme?
Tus Insulin Receptor thiab Mechanism of Action Cov insulin receptor yog tyrosine kinase. Hauv lwm lo lus, nws ua haujlwm raws li ib qho enzyme uas hloov phosphate pawg los ntawm ATP mus rau tyrosine residues ntawm intracellular phiaj proteins.
Cov tshuaj insulin puas tuaj yeem sib xyaw ua ke?
Nrog koj tus kws kho mob cov lus qhia, ntau qhov sib xyaw ntawm ob hom insulin tuaj yeem sib xyaw ua ke hauv tib lub koob txhaj tshuajthiab muab ua ib qho tshuaj. Ib zaug sib xyaw, kev txhaj tshuaj ua ke yuav tsum tau muab tam sim lossis cov txiaj ntsig ntawm cov tshuaj tiv thaiv ib txwm muaj yuav ploj zuj zus.
Kuv puas tuaj yeem ua xua rau insulin?
Kev tsis haum rau tib neeg cov tshuaj insulin lossis nws cov analogs tsis tshua muaj, nrog kwv yees qhov tshwm sim ntawm <1% mus rau 2.4% hauv cov neeg mob ntshav qab zib insulin. Txawm li cas los xij, cov xwm txheej ntawm cov tshuaj insulin txuas ntxiv tau tshaj tawm thiab ntau yam los ntawm qhov chaw txhaj tshuaj hauv zos rau kev ua rau muaj kev phom sij rau lub neej.
